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VEGF和VEGF-C表达与乳腺浸润性导管癌浸润转移关系的研究
引用本文:韩艳春,刘鲁英,吴淑华,杨东霞.VEGF和VEGF-C表达与乳腺浸润性导管癌浸润转移关系的研究[J].滨州医学院学报,2010,33(2):90-92.
作者姓名:韩艳春  刘鲁英  吴淑华  杨东霞
作者单位:滨州医学院病理学教研室,滨州市,256603;滨州医学院病理学教研室,滨州市,256603;滨州医学院病理学教研室,滨州市,256603;滨州医学院病理学教研室,滨州市,256603
摘    要:目的探讨血管内皮生长因子(VEGF)、VEGF-C在乳腺浸润性导管癌中表达及其与乳腺癌临床病理因素的关系。方法应用免疫组织化学S-P法检测70例乳腺浸润性导管癌组织中VEGF、VEGF-C蛋白表达,并结合临床生物学特征进行分析。结果乳腺浸润性导管癌组织中VEGF及VEGF-C蛋白表达的阳性率分别为70.0%和67.0%。VEGF表达与乳腺浸润性导管癌的肿瘤大小、临床分期、淋巴结转移有关(P<0.01),与患者年龄无显著相关性;VEGF-C表达乳腺浸润性导管癌的临床分期(P<0.05)、淋巴结转移有关(P<0.01),而与患者年龄、肿瘤大小无显著相关性。且VEGF和VEGF-C表达存在正相关(r=0.405,P=0.001)。结论VEGF、VEGF-C在乳腺浸润性导管癌中表达增强,在乳腺癌的浸润转移中起重要作用。

关 键 词:血管内皮生长因子  VEGF-C  乳腺癌  浸润  转移

Expression of vascular endothelial growth factor and vascular endothelial growth factor C in breast invasive ductal carcinoma and the relationship with tumor invasion and metastasis
Institution:HAN Yanchun LIU Luying WU Shuhua YANG Dongxia Department of Pathology,Binzhou Medical University,Binzhou 256603
Abstract:Objective To explore the expression of vascular endothelial growth factor and vascular endothelial growth factor C in breast invasive ductal carcinoma and to reveal their correlation to the major clinicopathological characteristics.Methods Expression of VEGF and VEGF-C was examined in the tissue sections from 70 cases of human breast invasive ductal carcinoma using streptoavidin-biotin-peroxidase immunohistochemistry method,and analyse their correlation to clinicopathological characteristics of breast carcinoma.Results The positive rate of VEGF and VEGF-C expression in breast invasive ductal carcinoma tissues was 70.0% and 67.0%,respectively.The expression of VEGF was related to tumor size,lymph node metastasis and TNM stage(P<0.01),and it was not related to age of patients.The expression of VEGF-C was related to TNM stage(P<0.05)and lymph node metastasis(P<0.01),and it was not related to age of patients and tumor size.A significance correlation was found between VEGF and VEGF-C expression(r=0.405,P=0.001).Conclusion Expression of VEGF and VEGF-C were increased in breast invasive ductal carcinoma.VEGF and VEGF-C may play an important role in the invasion and metastasis of breast carcionma.
Keywords:VEGF-C
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