| 阿魏酸钠对兔急性心肌梗死再灌注后无复流的影响 |
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| 引用本文： | 丁玲岩,刘现亮,赵希军,王连文,韩兆东,曾璟.阿魏酸钠对兔急性心肌梗死再灌注后无复流的影响[J].滨州医学院学报,2009,32(2). |
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| 作者姓名： | 丁玲岩 刘现亮 赵希军 王连文 韩兆东 曾璟 |
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| 作者单位： | 滨州医学院附属医院心内科,滨州市,256603;滨州医学院附属医院核医学科;滨州医学院附属医院中心实验室 |
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| 摘 要： | 目的 探讨阿魏酸钠对兔急性心肌梗死(acute myocardial infarction,AMI )再灌注后无复流的作用及机制.方法 随机将24只成熟雄性新西兰大白兔分为假手术组、对照组、阿魏酸钠组3组,每组8只,分别建立AMI缺血再灌注模型,于缺血前5min、结扎后240 min,再灌注后120 min取静脉血.采用酶联免疫吸附法(ELISA)测定血清白介素-6(IL-6);免疫组织化学法观察心肌组织P-选择素(Ps)的变化;应用硫黄素染色评估无复流面积.结果 ①对照组和阿魏酸钠组AMI后240 min、再灌注后120 min的血清IL-6均显著高于假手术组(P均＜0.01);阿魏酸钠组各时间点除AMI前血清IL-6均显著低于对照组(P均＜0.05).②Ps免疫组化显示,对照组及阿魏酸钠组中,Ps在复流区及无复流区血管内皮细胞有强表达,明显强于正常区及假手术组(P均＜0.01);阿魏酸钠组与对照组比较,Ps在复流区及无复流区表达均明显减弱(P均＜0.01).③病理染色分析示,阿魏酸钠组结扎区心肌范围与对照组相比差异无统计学意义(P均＞0.05);无复流区心肌范围与对照组相比显著降低(P均＜0.01 ).结论 阿魏酸钠能有效抑制炎症反应,防治AMI再灌注后无复流.
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| 关 键 词： | 阿魏酸钠 炎症 白介素-6 P-选择素 无复流 |
Effect of sodium ferulate on no-reflow in a rabbit model of acute myocardial infarction and reperfusion |
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| DING Lingyan LIU Xianliang ZHAO Xijun et al.Effect of sodium ferulate on no-reflow in a rabbit model of acute myocardial infarction and reperfusion[J].Journal of Binzhou Medical College,2009,32(2). |
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| Authors: | DING Lingyan LIU Xianliang ZHAO Xijun |
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| Institution: | DING Lingyan LIU Xianliang ZHAO Xijun et al Department of Cardiovascular Medical,Affiliated Hospital of Binzhou Medical University,Binzhou 256603 |
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| Abstract: | Objective To evaluate effects of sodium ferulate on no-reflow phenomenon in a rabbit model of acute myocardial infarction and reperfusion.Methods Twenty-four mature male rabbits were randomly divided into sham-operated group,control group,sodium ferulate group with 8 in each group.The later groups were subjected to 240 minutes of left circumflex coronary artery(LCX) occlusion followed by 120 minutes of reperfusion.The serum levels of IL-6 were measured by ELISA;To observe myocardial P-selectin(Ps) by immuno... |
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| Keywords: | sodium ferulate inflammation interleukin-6 P-selectin no-reflow |
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