| 制动应刺激造成兔肺脂肪栓塞的实验研究 |
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| 引用本文： | 薛红,张亚霏.制动应刺激造成兔肺脂肪栓塞的实验研究[J].第二军医大学学报,1988(4). |
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| 作者姓名： | 薛红 张亚霏 |
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| 作者单位： | 第二军医大学病理生理学教研室
(薛红)，第二军医大学病理生理学教研室(张亚霏) |
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| 摘 要： | 本研究首次应用制动应激的力法,建立了家兔非创伤肺脂肪栓塞的实验模型。同时测定了左、右心血肝素后血浆脂蛋白酯酶(PHP-LPL)活性和游离脂肪酸(FFA)浓度。结合血浆儿茶酚胺的测定、血气分析、肺形态学(包括超微结构)和组织化学的研究,探讨了肺脂肪栓塞的发生机理。实验观察到,制动应激5h可造成成年家兔肺血管内脂肪栓塞,同时伴有肺环循中PHP-LPL活性和FFA浓度增高,低碳酸血症、及肺泡表面活性物质不足的倾向。结果提示,应激时的内环境紊乱,足以造成肺脂肪栓塞,而无须骨折等机械因素的参与。
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| 关 键 词： | 脂肪栓塞 制动应激 脂蛋白酯酶 家兔 动物疾病模型 |
PULMONARY FAT EMBOLISM INDUCED BY FORCED IMMOBlLIZATION IN RABBITS |
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| Xue Hong,.PULMONARY FAT EMBOLISM INDUCED BY FORCED IMMOBlLIZATION IN RABBITS[J].Academic Journal of Second Military Medical University,1988(4). |
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| Authors: | Xue Hong |
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| Institution: | Department of Pathophysiology |
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| Abstract: | In the present study, forced immobilization induced-pul-monary fat embolism as an experimental model was developed for the first time in rabbits.The area of emboli was calculated by an electronic caculator.At the same time, the activities of lipoprotein lipase in post-heparin plasma (PHP-LPL) and the concentrations of free fatty acids(FFA)were measured,The determination of plasma catecholamines, the analysis of blood gas, the observation of pulmonary morphology (including ultrastructure)were also carried out,It was found that forced immobilization for 5h could induced pulmonary embolism in rabbits, accompanied by the elevation of PHP-LPL and FFA in pulmonary circulation, hypocapnia, and the tendency of surfactant insufficiency.The results suggest that the disorder of homeostasis caused by stress is strong enough to induce pulmonary embolism without the participation of fracture |
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| Keywords: | fat embolism forced immobilization stress lipoprotein lipase rabbits |
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