| 孕妇外周血中胎儿游离DNA在产前诊断中的应用 |
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| 引用本文： | 王文博,张毅,孙树汉.孕妇外周血中胎儿游离DNA在产前诊断中的应用[J].第二军医大学学报,2009,30(4):442-446. |
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| 作者姓名： | 王文博 张毅 孙树汉 |
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| 作者单位： | 1. 第二军医大学学员十队,上海,200433;第二军医大学基础部医学遗传学教研室,上海,200433
2. 第二军医大学基础部医学遗传学教研室,上海,200433 |
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| 基金项目： | 国家科技支撑计划（2006BAI05A05）. |
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| 摘 要： | 孕妇外周血中胎儿游离DNA的发现，为无创性产前诊断开辟了一条新途径。检测孕妇血浆中特异的胎儿DNA序列已被用于胎儿性连锁疾病鉴定、RhD血型检查和多种单基因遗传病的产前诊断；游离DNA水平的变化还可被用作某些妊娠相关疾病如先兆子、早产和胎儿染色体疾病的临床诊断新指标。本文对母体外周血中胎儿游离DNA的生化特征及其临床应用研究，进行了总结和分析。
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| 关 键 词： | 胎儿游离DNA 游离核酸 无创性产前诊断 基因诊断 孕妇血浆 |
| 收稿时间： | 9/27/2008 5:28:01 PM |
| 修稿时间： | 2009/2/16 0:00:00 |
Prenatal diagnosis value of free fetal DNA in maternal blood |
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| WANG Wen-bo,ZHANG Yi,SUN Shu-han.Prenatal diagnosis value of free fetal DNA in maternal blood[J].Academic Journal of Second Military Medical University,2009,30(4):442-446. |
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| Authors: | WANG Wen-bo ZHANG Yi SUN Shu-han |
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| Institution: | 1. No.10 Student Team, Second Military Medical University, Shanghai 200433, China;2. Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433 |
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| Abstract: | The discovery of circulating fetal DNA paves a new way for non-invasive prenatal diagnosis. Examining the specific fetal DNA sequence of the circulating fetal DNA has been used for prenatal diagnosis of sex-linked disorders, fetal rhesus D blood typing and single gene inheritance disease. The variation of the circulating DNA levels can also be used for diagnosis of preeclampsia, premature delivery, and fetal chromosome disorders. This paper aims to review the biochemistry characters and clinical application of the circulating fetal DNA in maternal peripheral plasma. |
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| Keywords: | cell-free fetal DNA circulating nucleic acid non-invasive prenatal diagnosis gene diagnosis maternal blood |
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