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自制镍钛合金室间隔缺损封堵器的生物相容性研究
引用本文:秦永文,胡建强,赵仙先.自制镍钛合金室间隔缺损封堵器的生物相容性研究[J].第二军医大学学报,2001,22(11):1038-1040.
作者姓名:秦永文  胡建强  赵仙先
作者单位:第二军医大学长海医院心血管内科,
基金项目:上海市科技攻关基金资助项目 ( 0 14 1190 0 3)
摘    要:目的:观察自制室间隔缺损封堵器植入动物体内后的组织学反应。方法:选用杂种猪6只,体重量15~20kg。应用硫喷妥钠静脉麻醉,开胸暴露心脏,在右心室近心尖处穿刺右心室壁、室间隔,通过10F鞘管将自制镍钛合金室间隔缺损封堵器置入室间隔处。观察45~120d。结果:6只猪中1只困术中出血死亡,另1只猪术后8h死亡;4只猪存活。术后45d和60d各处死1只猪,120d处死2只,大体标本显示封堵器表面覆盖一层新生内膜,光镜观察新生内膜表面为一单层扁平细胞所覆盖。在早期、封堵器植入处有炎症细胞浸润;后期炎症反应消失,为纤维组织所代替,表现为组织损伤后的修复过程。肺、肝脏、脾脏、肾脏、大小肠无血栓栓塞现象。结论:自制镍钛合金室间隔缺损封堵器有很好的生物相容性。

关 键 词:镍钛合金  室间隔缺损  封堵器  生物相容性材料
文章编号:0258-879(2001)11-1038-03
修稿时间:2001年4月9日

Study on the biocompatibility of self-made nitinol alloy ventricular septal defect occluder
QIN Yong Wen,HU Jian Qiang,ZHAO Xian Xian.Study on the biocompatibility of self-made nitinol alloy ventricular septal defect occluder[J].Academic Journal of Second Military Medical University,2001,22(11):1038-1040.
Authors:QIN Yong Wen  HU Jian Qiang  ZHAO Xian Xian
Abstract:Objective: To evaluate the biocompatibility of self made nitinol alloy ventricular septal defect occluder. Methods: Six nitinol alloy ventricular septal defect occluder were implanted in the ventricular septum by catheter in 6 normal anaesthetized open chest pigs, and the animals were observed for 45 to 120 d(2 animals). Results: One deaths resulted from hemorrhage and another from embolization of occluder in abdominal aorta during the placement procedure. Successful placement of the occluder was achieved in 4 animals. Four animals were killed at 45, 60 and 120 d. Postmortem gross and microscopic examination of 4 devices 45 to 120 d after placement showed that both the right and left ventricular discs of the occluder were completely covered by a smooth, shiny, glistening thin layer of neoendocardium, and the surface of neoendocardium was covered by a monolayer of endothelium like cells. The inflammatory infiltrate around the occluder was found at 45 d, and disappeared and fibrosis formed at 120 d. These appeared as a repair process of the injury. Embolization in lung,liver, spleen, kidney, intestinal and colon were not found. Conclusion: These suggest that the self made nitinol alloy ventricular septal defect occluder has good biocompatibility.
Keywords:nitinol alloy  heart septal defects  ventricular  occluder  biocompatible materials
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