| 布比卡因聚乳酸缓释微球的制备及体外释药研究 |
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| 引用本文： | 俞媛,高申,钟延强,丁雪鹰.布比卡因聚乳酸缓释微球的制备及体外释药研究[J].第二军医大学学报,2002,23(1):87-89. |
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| 作者姓名： | 俞媛 高申 钟延强 丁雪鹰 |
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| 作者单位： | 第二军医大学药学院药剂学教研室,上海,200433 |
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| 摘 要： | 目的:制备布比卡因聚乳酸缓释微球,并对其体外释药特性进行考察.方法:以聚乳酸为载体,采用W/O/W乳剂-扩散溶剂挥发法制备布比卡因聚乳酸缓释微球,考察了微球的粉粒学特征,并进行了体外溶出研究.结果:差热分析表明,布比卡因在载体中以分子状态存在,与聚乳酸形成了包嵌的微球体;其体外释药曲线可用Higuchi方程拟合,t1/2=22.76 h.结论:布比卡因聚乳酸缓释微球体外具有缓释作用.
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| 关 键 词： | 布比卡因、微球体、体外研究、迟效制剂 |
| 文章编号： | 0258-879X(2002)01-0087-03 |
| 修稿时间： | 2001年6月26日 |
Preparation and evaluation of sustained-release polylactic acid microspheres of bupivacaine in vitro |
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| YU Yuan,GAO Shen,ZHONG Yan-Qiang,DING Xue-Ying.Preparation and evaluation of sustained-release polylactic acid microspheres of bupivacaine in vitro[J].Academic Journal of Second Military Medical University,2002,23(1):87-89. |
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| Authors: | YU Yuan GAO Shen ZHONG Yan-Qiang DING Xue-Ying |
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| Abstract: | Objective: To prepare sustained-release polylactic acid microspheres containing bupivacaine (BUP-PLA-MS) and to measure its dissolution in vitro. Methods: BUP-PLA-MS was prepared with polylactic acid (PLA) as carriers using the water-in-oil-in-water (W/O/W) emulsion solvent evaporation method. The powder particle characteristics of BUP-PLA-MS were evaluated comprehensively, and its dissolution characteristics in vitro were studied. Results: It was indicated that bupivacaine formed molecular dispersion within PLA matrix by differential thermal analysis(DTA). The in vitro release behavior of bupivacaine could be best described by Higuchi equation, with t 1/2 =22.76 h. Conclusion: Release of bupivacaine from microspheres is sustained in vitro. |
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| Keywords: | bupivacaine microspheres in vitro delayed-action preparations |
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