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眼用氟尿嘧啶的制备及体外评价
引用本文:黄潇,魏锐利,魏锐利.眼用氟尿嘧啶的制备及体外评价[J].第二军医大学学报,2008,29(10):1227-1229.
作者姓名:黄潇  魏锐利  魏锐利
作者单位:第二军医大学长征医院眼科,上海,200003
基金项目:上海市纳米科技专项基金,解放军医药卫生科研项目
摘    要:目的:应用滴入分散法制备眼用氟尿嘧啶一壳聚糖纳米粒(5一Fu-CS-NP),并对其体外释放进行考察.方法:将壳聚糖、聚丙烯酸与氟尿嘧啶通过滴入分散法形成聚电解质络合物制备5-Fu-CS-NP.考察纳米粒粒径、包封率、载药量以及体外释药特性.结果和结论:5一Fu-CS-NP平均粒径为(144.6士3.1)nm,包封率为84.5%,载药量为3.91%.5-Fu-CS-NP有较好的缓释作用,能在3~7 d内持续释放药物.在pH值7.2~7.4的生理范围内释放速率变化不大.

关 键 词:氟尿嘧啶  壳聚糖  聚丙烯酸  纳米技术  后囊膜混浊
收稿时间:2/1/2008 12:00:00 AM
修稿时间:2008/5/19 0:00:00

Preparation and in vitro evaluation of fluorouracil nanoparticles for ophthalmologic usage
HUANG Xiao,WEI Rui-li and weiruili.Preparation and in vitro evaluation of fluorouracil nanoparticles for ophthalmologic usage[J].Academic Journal of Second Military Medical University,2008,29(10):1227-1229.
Authors:HUANG Xiao  WEI Rui-li and weiruili
Institution:Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Abstract:Objective:To prepare fluorouracil-loaded chitosan nanoparticle (5-Fu-CS-NP) for ophthalmologic usage and evaluate its releasing characteristics in vitro. Methods: 5-Fu-CS-NP was prepared with 5-Fu, polyacrylic acid and chitosan using dispersion method. The mean size, entrapment efficiency (EE%), drug loading (DL%) and the in vitro releasing characteristics of 5-Fu-CS-NP were investigated.Results and conclusion: The mean size of 5-Fu-CS-NP was (144.6±3.1) nm, the EE% was 84.5% and the DL% was 3.91%. 5-Fu-CS-NP had a satisfactory sustained-releasing effect and the releasing could last for 3-7 days, and the release behavior was not greatly changed within a pH value of 7.2-7.4.
Keywords:fluorouracil  chitosan  polyacrylic acid  nanotechnology  posterior capsule opacification
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