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| 姜黄素对缺血再灌注大鼠脑组织SOD,MDA和亚硝酸盐含量的影响 | |
| 引用本文： | 石晶,陶沂,胡晋红,田亚平. 姜黄素对缺血再灌注大鼠脑组织SOD,MDA和亚硝酸盐含量的影响[J]. 第二军医大学学报, 1999, 20(6): 386-387 |
| 作者姓名： | 石晶 陶沂 胡晋红 田亚平 |
| 作者单位： | 1. 第二军医大学长海医院药学部,上海,200433 2. 第二军医大学长海医院神经内科 3. 解放军总医院生化科 |
| 摘 要： | 目的：通过观察姜黄素对脑缺血再灌注时脑组织中丙二醛,亚硝酸盐,超氧化物歧化酶含量的影响,探讨其对再灌注损伤保护作用的机制。方法：选用大鼠４血管结扎缺血再灌注模型,用化学发光法测定大鼠脑组织中ＳＯＤ的活性,用比色法测定ＭＤＡ和亚硝酸盐的含量。姜黄素于缺血前３０ｍｉｎ腹腔注射给予。结果：缺血３０ｍｉｎ再灌注１５ｍｉｎ后,模型组的动物脑组织中ＭＤＡ和亚硝酸盐的含量明显升高。 |
| 关 键 词： | 姜黄素 脑缺血 再灌注损伤 脂质过氧化物 一氧化氮 超氧化物歧化酶 |
Effects of curcumin on contents of SOD, MDA and nitrite in the brain of cerebral ischemia reperfusion rats |
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| Shi Jing,Tao Yi,Hu Jinhong,Tian Yaping. Effects of curcumin on contents of SOD, MDA and nitrite in the brain of cerebral ischemia reperfusion rats[J]. Former Academic Journal of Second Military Medical University, 1999, 20(6): 386-387 | |
| Authors: | Shi Jing Tao Yi Hu Jinhong Tian Yaping |
| Abstract: | Objective: To investigate the protective mechanism of curcumin on ischemia reperfusion injury in rats. Methods: The 4 vessel occlusion rat model was used, and the contents of malonaldehyde(MDA), nitrite and SOD in brain tissue were detected after 30 min ischemia and 15 min reperfusion with spectrophotometry and chemoluminescence respectively. Curcumin was given (20 or 40 mg/kg) intraperitoneally 30 min before ischemia. Results: The contents of MDA and nitrite in the brain were significantly increased after ischemia and reperfusion, while this increase was inhibited in curcumin treated groups. The activity of SOD in brain of curcumin groups was elevated. Conclusion: The protective effect of curcumin in cerebral ischemia reperfusion injury might be related to its inhibiting activity on radical generation and radical eleminating action. |
| Keywords: | curcumin cerebral ischemia reperfusion injury lipid peroxide nitric oxide superoxide dismutase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |