| Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats |
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| 作者姓名： | Yang J Wang WZ Shen FM Su DF |
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| 作者单位： | Department of Pharmacology, Second Military Medical University, Shanghai 200433,China |
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| 摘 要： | Agmatine was isolated from bovine brain in 1994. It exhibits various functions, as a consequence of which it meets the criteria for an endogenous brain neurotransmitter. However, its physiological action on the cardiovascular system remains unclear. This study was designed to clarify its cardiovascular effects when administered into the rostral ventrolateral medulla （RVLM） in anesthetized and paralyzed rats. Unilateral injection of clonidine （5 nmol） into the RVLM significantly decreased mean arterial pressure （MAP） and heart rate （HR）.
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| 关 键 词： | 腹膜外骨髓 氯压定 降压药 麻痹 心脏血管疾病 |
Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats |
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| Yang J Wang WZ Shen FM Su DF.Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats[J].Academic Journal of Second Military Medical University,2005,26(10):1200-1200. |
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| Authors: | Yang;J;Wang;WZ;Shen;FM;Su;DF |
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