三维数字人脑模型的构建与验证

目的构建、验证并优化3-D数字人脑模型,为准确展示人脑组织、指导临床实践奠定基础。方法以1例24岁健康成年志愿者头颅MRI T1加权二维断层图像176张图片为原始数据,联合应用Mimics 8.0、Z-brush、Imageware、Photoshop、Maya 8.5等软件对原始图像进行预处理,精准分割目标结构,进行三维重建形成3-D粗模,对粗模进行雕刻,模型验证后进行3-D彩绘和选染等加工。结果根据176张原始图像数据成功完成了人脑组织三维模型的重建,经验证计算所得的模型轮廓线与原始图像边缘吻合较好,经过3-D彩绘和渲染后所得模型具有较好的展示度。所建模型可任意旋转、放缩,从各个角度观察。结论成功构建出准确性高、展示度好的仿真人脑及部分相邻器官的三维模型,为后续指导临床实践奠定了基础。

Construction and verification of a three-dimensional digital human brain atlas

ObjectiveTo construct, verify and optimize an interactive three-dimensional(3-D) digital anatomic model of human brain, so as to pave a way for accurate display of the cerebral tissues and for guiding clinical practice. MethodsA series of 176 sections(T1WI)of a healthy male volunteer, who aged 24 years old and underwent 1.5 T General Electric Signa MRI examination, were used as the original data, which were pretreated using commercially available software (Mimics 8.0, Z-brush, Imageware, Photoshop and Maya 8.5). The rough model was established and was adjusted. After verification, the model was subjected to 3-D painting and rendering. ResultsThe 3-D model of human brain was successfully constructed based on the 176 original images. The outline calculated according to the model corresponded well with the edge of the original MRI image. After painting and rendering, the 3-D model showed a satisfactory display efficacy. The model could be viewed from any angle and could be rotated 360 degrees in any plane. Moreover, it could be rotated, reduced and enlarged using the zoom function, allow viewing from different directions. ConclusionWe have successfully constructed a 3-D model of the human brain and some adjacent organs with high accuracy and satisfactory displays efficacy, which lays a foundation for guiding future clinical practice.