ATP2A2通过钙离子浓度变化参与肿瘤发生机制的研究进展

ATP2A2是ATP2As基因家族的成员,编码肌浆(内质)网钙转运ATP酶中的一种，即SERCA2b。由于该酶的主要功能为将钙离子从胞质转运至肌浆(内质)网内，因而它在控制肿瘤生长、分化、血管生成、转移和凋亡的钙离子相关信号通路中发挥着重要作用。近期研究已在一些类型的肿瘤中明确了ATP2A2表达水平的具体变化，在探究ATP2A2是如何参与肿瘤形成以及它是否可作为肿瘤标记物和治疗靶点方面迈出了第一步。本文对ATP2A2参与肿瘤发生的可能机制的相关研究进行了总结，认为其表达异常可引起细胞胞质内和内质网间钙离子稳态的破坏，从而造成细胞的恶性增殖并促进肿瘤的迁移和血管形成等。本文还对该基因的研究和应用前景进行了展望。

Ca2+-dependent ATP2A2 pathway in tumorigenesis: an update

ATP2A2 is a member of ATP2As family; it encodes SERCA2b,a sarco(endo)plasmic reticulum calcium transport ATPases (SERCAs). As the main function of SERCA2b is to transport calcium from the cytosol to the sarco(endo)plasmic reticulum, it plays a vital role in numerous calcium-related signaling pathways involving control of tumor growth, differentiation, angiogenesis, metastasis and apoptosis. Recent studies have identified the accurate change of ATP2A2 expression in some tumors, which makes the first step in investigating how ATP2A2 participates in tumorigenesis and whether it can be taken as a new tumor marker and target for treatment. Here we made a comprehensive review on the role of ATP2A2 in tumorigenesis, and it is believed that the abnormal expression of ATP2A2 can damage the calcium homeostasis between cytosol and sarco (endo) plasmic reticulum, accelerating malignant proliferation, migration and angiogenesis of the tumor. Moreover, we also discussed the prospect of research and application of ATP2A2.