| Survivin在人原发性肝细胞癌中的表达及其与凋亡的相关性 |
| |
| 引用本文： | 李春生,倪灿荣.Survivin在人原发性肝细胞癌中的表达及其与凋亡的相关性[J].第二军医大学学报,2003,24(9):1044-1044,F003. |
| |
| 作者姓名： | 李春生 倪灿荣 |
| |
| 作者单位： | 1. 舟山市人民医院病理科,舟山,316000
2. 第二军医大学长海医院病理科,上海,200433 |
| |
| 摘 要： | 利用免疫组化(IHC)-EnVision法和Tunel法检测了68例原发性肝细胞癌(HCC)和癌旁肝组织及12例正常肝组织中Survivin、PcNA、Bcl-xl,探讨Survivin基因在肝组织细胞中的表达与凋亡指数(AI)、增殖指数(PI)和凋亡抑制因子的相关性.结果发现Survivin和Bcl-xl在HCC中阳性检测率分别为58.8％(40/68)和48.5％(33/68),高于癌旁肝组织分别为5.88％(4/68)和36.8％(25/68)]及正常肝组织0(0/12)和25％(3/12)].Survivin和Bcl-xl主要表达在细胞质或细胞膜上.Survivin的阳性表达与HCC的侵袭转移倾向、AI以及 Bcl-xl有关(P＜0.05,P＜0.01),而与PI无关.
|
| 关 键 词： | 肝细胞癌、细胞凋亡、增殖、Bcl-xl、Survivin |
| 文章编号： | 0258-879X(2003)09-1044-02 |
Expression of survivin gene in human primary hepatic carcinoma and its relotionship with apoptosis |
| |
| LI Chun Sheng ,NI Can Rong.Expression of survivin gene in human primary hepatic carcinoma and its relotionship with apoptosis[J].Academic Journal of Second Military Medical University,2003,24(9):1044-1044,F003. |
| |
| Authors: | LI Chun Sheng NI Can Rong |
| |
| Institution: | LI Chun Sheng 1,NI Can Rong 2 |
| |
| Abstract: | The expressions of survivin,PcNA and Bcl xl were detected in 68 patients with pramary hepatic careinoma(HCC) and adjacent tissues and 12 cases of normal hepatic tissues by immunohistochemical (IHC) EnVision and Tunel method.The relationship between survivin gene expression and apoptosis index(AI),proliferation index(PI) and apoptosis inhibition factors were studied.The positive rate of survivin and Bcl xl expression were 58.8%(40/86) and 48.5%(33/68) in HCC,5.88%(4/68) and 36.8%(25/68) in adjacent tissues,0 (0/12) and 25%(3/12) in normal hepatic tissues.The expression of Survivin and Bcl xl are mainly in cell membrane and cytoplasm.Survivin expression is related to metastasis of HCC ( P < 0.05), AI and Bcl xl expressron( P <0.01),but is not related with PI. |
| |
| Keywords: | hepatocellular carcinoma apoptosis proliferation Bcl xl Survivin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
| 点击此处可从《第二军医大学学报》下载免费的PDF全文 |
