卒中危险因素对脑血流动力学指标的影响

目的：分析卒中危险因素对脑血管血流动力学检测各指标(CVHI)及总积分的影响。方法：以整群抽样的方法抽取上海市南汇区芦潮港、彭镇、泥城、书院、大团5个镇35岁及以上人群中的11651例，进行卒中危险因素的调查，检测CVHI指标，对检测指标进行积分，分析不同卒中危险因素暴露水平对CVHI各检测指标和总积分的影响。结果：高血压、心脏病、糖尿病、卒中家族史、吸烟危险因素的暴露率分别为48．16％、11．67％、4．50％、10．45％和16．34％。高血压、心脏病和糖尿病暴露使脑血管最大血流速度(Vmax)、最小血流速度(Vmin)以及舒张压与临界压的差值(DP)等下降，使脉搏波波速(WV)、外周阻力(Rv)、特异性阻抗(Zcv)、动态阻力(DR)、临界压水平(CP)等指标上升。危险因素聚集使CVHI的变化加重。使CVHI总积分降低的危险因素分别为高血压、心脏病、糖尿病和年龄、男性。结论：高血压、心脏病、糖尿病对CVHI单项指标和总积分均有不同程度的影响。

Effect of stroke risk factors on cerebral vascular hemodynamic indexes

Objective: To analyze the effect of stroke risks factor on cerebral vascular hemodynamic indexes (CVHI). Methods: Totally 11 651 participants aged 35 years and over were selected from 5 towns of Nanhui county in Shanghai city, namely Luchaogang,Pengzhen,Nicheng,Shuyuan and Datuan. Risk factors of stroke were investigated and CVHI were examined. Accumulative score of CVHI was estimated. Effect of stroke risk factors on CVHI and its accumulative score were analyzed. Results: Exposure rate of hypertension, heart disease, diabetes, family history of stroke and cigarette smoking were 48. 16%,11. 67%,4. 50%, 10. 45% and 16. 34%, respectively. Vmax, Vmin and DP in participants with history of hypertension, heart disease, diabetes were lower than that without it. However, WV,Rv,Zcv,DR,and CP were higher in exposure group than that of without exposure. Cluster of stroke risk factors made CVHI changes more significant. The risk factors decreasing CVHI score were hypertension, heart disease, diabetes, age and male sex. Conclusion: Exposure to hypertension,heart disease,diabetes has effect of different degree on both CVHI and its accumulative score.