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90Y标记OSMcAb的研究
引用本文:纪方,苗积生,史丽梅.90Y标记OSMcAb的研究[J].第二军医大学学报,2000,21(2):162-165.
作者姓名:纪方  苗积生  史丽梅
作者单位:[1]第二军医大学长海医院骨科 [2]上海第一肺科医院免疫室
摘    要:研究放射性核素^90Y标民骨肉瘤单克隆抗体(OSMcAb)的条件及方法。方法采用EDTA淋洗法从^90Y发生器上制备了^90Y,并用DTPA环酐法将^90Y标记抗人成骨肉瘤单克隆抗体。标记后的单抗进行体外靶细胞结合实验以验证标记后单抗蛋白活保持程度。

关 键 词:放射性核素标记  骨肉瘤  单克隆抗体  Y90
文章编号:0258-879X(2000)02-0162-04
修稿时间:1999-08-10

Study on OSMcAb labeled with Yttrium-90
JI Fang ,MIAO Ji Sheng ,SHI Li Mei ,SHEN Qian ,CHEN Yong Yu ,CHEN Jian.Study on OSMcAb labeled with Yttrium-90[J].Academic Journal of Second Military Medical University,2000,21(2):162-165.
Authors:JI Fang  MIAO Ji Sheng  SHI Li Mei  SHEN Qian  CHEN Yong Yu  CHEN Jian
Institution:JI Fang 1,MIAO Ji Sheng 2,SHI Li Mei 3,SHEN Qian 4,CHEN Yong Yu 1,CHEN Jian 4
Abstract:Objective: To study DTPA coupled OSMcAb labeled with 90 Y. Methods: Carrier free 90 Y was obtained from its 90 Y/ 90 Sr generator and DTPA coupled OSMcAb was labeled with carrier free 90 Y. The protein activity of 90 Y DSMcAb was researched through the test of tumor cell OSMcAb in vitro . The specific of 90 Y DSMcAb was investigated with biodistribution in vivo . Results: (1) The 90 Y activity was higher while the contumination of 90 Sr was less than 0.003 1%; (2) The efficiency of 90 Y labeled antibodies was more than 90%; (3) The activity of labeled antibody maintained 82.3%. (4) 90 Y radioisotopes concentrated in tumor targeted by OsMcAb. Conclusion: OsMcAb can be successfully labeled with 90 Y by singgcyclic DTPA chelation.
Keywords:antibody  monoclonal  yttrium radioisotopes  radioisotopes labeling  osteosarcoma
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