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| 肺癌相关基因的表达谱研究 | |
| 引用本文： | 黄达蔷,戴建凉,陈菊祥,田立峰,金杨晟,沈娴,应康,谢毅,毛裕民.肺癌相关基因的表达谱研究[J].第二军医大学学报,2000,21(9):827-830,I001. |
| 作者姓名： | 黄达蔷 戴建凉 陈菊祥 田立峰 金杨晟 沈娴 应康 谢毅 毛裕民 |
| 作者单位： | 1. 联合基因科技(集团)有限公司,上海,200092 2. 复旦大学遗传学研究所 3. 第二军医大学长征医院 |
| 基金项目： | 国家科技部科技型中小企业创新基金!资助项目( 0 0 C 2 62 13 10 0 65 ) |
| 摘 要： | 目的：通过研究人肺癌组织和正常组织中差异表达的基因，寻找肺癌相关基因以用于肺癌的诊断和治疗。方法：以包含４０９６个ｃＤＮＡ基因表达谱芯片研究一组肺癌组织样本的基因表达谱。结果：共筛选出差异表达的基因３７０条，包含已知基因１４６条，未知基因２２４条，其中１０７条表达增加，２６３条表达降低。结论：基于ｃＤＮＡ微矩阵技术的肿瘤基因表达谱分析能够高通量筛选与肺癌发生密切相关的基因。 |
| 关 键 词： | 微矩阵基因芯片 基因表达谱 肺肿瘤 |
Investigation on the gene expression pattern of human lung cancer |
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| HUANG Da-Qiang,DAI Jian-Liang,CHEN Ju-Xiang,TIAN Li-Feng,JIN Yang-Sheng,SHEN Xian,YING Kang,XIE Yi,MAO Yu-Min.Investigation on the gene expression pattern of human lung cancer[J].Academic Journal of Second Military Medical University,2000,21(9):827-830,I001. | |
| Authors: | HUANG Da-Qiang DAI Jian-Liang CHEN Ju-Xiang TIAN Li-Feng JIN Yang-Sheng SHEN Xian YING Kang XIE Yi MAO Yu-Min |
| Abstract: | Objective: To investigate the genes differentially expressed in lung cancer and determine some lung cancer associated genes which can be used for diagnosing and treating lung cancer. Methods: cDNA microarray chips containing numerous cDNAs were used to investigate the gene expression pattern of samples of human lung cancer. Results: Three hundred and seventy genes expressed in lung cancer were screened out, comprising 146 known genes, 224 unknown genes, among these genes, up and down regulated genes were 107 and 263, respectively. Conclusion: The analysis of gene expression pattern of tumor based on cDNA microarray can realize high throughput screening of the genes associated with the lung cancer. |
| Keywords: | gene chip cDNA microarray gene expression pattern lung cancer |
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