| 杀莠素A对兔软骨细胞增殖和产生NO的影响 |
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| 引用本文： | 王杰松,张俊平,张珉,钱定华.杀莠素A对兔软骨细胞增殖和产生NO的影响[J].第二军医大学学报,2000,21(6):572-574. |
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| 作者姓名： | 王杰松 张俊平 张珉 钱定华 |
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| 作者单位： | 第二军医大学药学院药理学教研室,上海,200433 |
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| 基金项目： | 国家自然科学基金!资助项目 (396 70 837) |
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| 摘 要： | 研究杀莠素Ａ对ＩＬ－１抑制软骨细胞增殖和诱导ＮＯ产生的作用。方法：ＩＬ－１单独或与杀莠素Ａ共育于软骨细胞,用结晶紫染色法测定软骨细胞增殖,Ｇｒｉｅｓｓ法测定ＮＯ的产生。结果：ＩＬ－１抑制软骨细胞增殖,杀莠素Ａ剂量依赖地逆转ＩＬ－１的作用。杀莠素Ａ还能剂量依赖地抑制ＩＬ－１诱导软骨细胞产生ＮＯ。结论：杀莠素Ａ逆转ＩＬ－１换制软骨细胞增殖的作用可能是通过ＮＯ介导的。
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| 关 键 词： | 杀莠素A 软骨细胞 IL－1 细胞增殖 一氧化氮 |
| 修稿时间： | 】 |
Effects of herbimycin A on proliferation and nitric oxide production stimulated by interleukin-1 in chondrocytes |
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| WANG Jie-Song,ZHANG Jun-Ping,ZHANG Min,QIAN Ding-Hua.Effects of herbimycin A on proliferation and nitric oxide production stimulated by interleukin-1 in chondrocytes[J].Academic Journal of Second Military Medical University,2000,21(6):572-574. |
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| Authors: | WANG Jie-Song ZHANG Jun-Ping ZHANG Min QIAN Ding-Hua |
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| Abstract: | Objective: To study the effects of herbimycin A on proliferation and NO production stimulated by IL 1 in chondrocytes. Methods: IL 1 alone or in combination with herbimycin A was administered.Chondrocytes proliferation was detected by crystal violet dying method and NO production was detected by Griess method. Results: IL 1 inhibited chondrocytes proliferation. Herbimycin A dose dependently reversed the effect. Also herbimycin A could inhibit NO production induced by IL 1. Conclusion: The reversing effect of herbimycin A on chondrocytes proliferation may be mediated by NO. |
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| Keywords: | herbimycin A chondrocytes IL 1 proliferation |
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