| 躯体性及心理性应激状态下大鼠胃粘膜NOS活性与胃粘膜损伤 |
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| 引用本文： | 聂时南,李兆申,许国铭,湛先保,屠振兴,龚燕芳,段义民,崔忠敏,刘枫.躯体性及心理性应激状态下大鼠胃粘膜NOS活性与胃粘膜损伤[J].第二军医大学学报,2000,21(1):10-12. |
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| 作者姓名： | 聂时南 李兆申 许国铭 湛先保 屠振兴 龚燕芳 段义民 崔忠敏 刘枫 |
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| 作者单位： | 第二军医大学长海医院消化内科,上海,200433 |
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| 基金项目： | 军队医药卫生杰出中青年人才科研基金!资助项目（1996 卫科训字95 号） |
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| 摘 要： | 目的：探讨躯体性及心理性应激状态下大鼠胃粘膜ＮＯＳ活性变化及其与胃粘膜损伤的关系。方法：将９６只雄性ＳＤ大鼠随机分为３组：对照组,规则光（Ｒ）组及不规则光（Ⅰ）组,采用高压恒流脉冲刺激器制备躯体性和心理性应激模型。分光光度法检测胃粘膜组织的ＮＯＳ活性和Ｎｉｌｓ Ｌａｍｂｅｃｈｔ法测定胃粘膜损伤指数。结果：正常情况下ＮＯＳ活性平稳,应激氏大鼠胃粘膜ＮＯＳ活笥均明显升高,Ⅰ组升高程度更明显;与对照组比
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| 关 键 词： | 一氧化氮合酶 胃粘膜 应激 胃溃疡 大鼠 |
| 文章编号： | 0258-879X(2000)01-0010-03 |
| 修稿时间： | 1999-08-26 |
Relation between the activity change of nitric oxide synthase (NOS) and acute gastric mucosal lesion in gastric mucosa under physical and psychological stress in rats |
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| NIE Shi-Nan,LI Zhao-Shen,XU Guo-Ming,ZHAN Xian-Bao,TU Zhen-Xing,GONG Yan-Fang,DUAN Yi-Min,CUI Zhong-Ming,LIU Feng.Relation between the activity change of nitric oxide synthase (NOS) and acute gastric mucosal lesion in gastric mucosa under physical and psychological stress in rats[J].Academic Journal of Second Military Medical University,2000,21(1):10-12. |
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| Authors: | NIE Shi-Nan LI Zhao-Shen XU Guo-Ming ZHAN Xian-Bao TU Zhen-Xing GONG Yan-Fang DUAN Yi-Min CUI Zhong-Ming LIU Feng |
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| Institution: | NIE Shi-Nan
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
LI Zhao-Shen
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
XU Guo-Ming
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
ZHAN Xian-Bao
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
TU Zhen-Xing
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
GONG Yan-Fang
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
DUAN Yi-Min
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
CUI Zhong-Ming
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China)
LIU Feng
(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,
Shanghai 200433, China) |
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| Abstract: | Objective: To explore the relation between the activity changes of nitric oxide synthase and acute gastric mucosal lesion in gastric mucosa under physical and psychological stress. Methods: Animal model was constructed with impulsive stimulator of high voltage and stable currency. Ninety six male SD rats were randomly divided into 3 groups: control, regular and irregular group. NOS activity was measured by spectrophotometry and injure of gastric mucosa was measured by method of Nils Lambecht. Results: NOS activity was stable in normal rats but increased significantly in group of psychological stress( P <0.05); gastric mucosa injury were observed in regular group, irregular group and the later was server( P < 0.05). Conclusion: The degree of increase of the NOS activity and gastric mucosa injury are positively correlated to the severity of psychological stress. |
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| Keywords: | nitric oxide synthase gastric mucosal stress |
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