硬膜外移植自体髓核对大鼠神经根结构和功能的影响

目的：探讨与椎间盘相关的腰腿痛的发病机制。方法：将大鼠自身的尾椎髓核取出置于硬膜外腔，造成非压迫性的大鼠硬膜外自体髓核移植模型，并对其马尾神经根诱发电位及组织形态学进行观察。结果：在无明显机械压迫的情况下，大鼠硬膜外移植自体髓核后能产生明显的马尾神经根诱发电位及组织形态学的改变。结论：髓核所致的免疫及（或）生化炎症是引起神经根损伤及产生腰腿痛的重要原因。

Effect of nucleus pulposus autograft to the cavum epidurale on the structure and function of nerve roots in rats

Objective: To find out the pathomechanism of low back and leg pain related to intervertebral disc. Methods: The nucleus pulposus of coccygeal vertebral was transplanted to the cavum epidurale of rats to establish the non compressive model with transplanted nucleus pulposus. The evoke potentials and morphology of nerve roots were observed. Results: Even without mechanical compression, rats transplanted with nucleus pulposus resulted in significant harm to evoked potential and morphology of cauda equina. Conclusion: The biomechanical and/or immunologic inflammatory effect of nucleus pulposus can result in nerve roots injury and is an important factor in the pathogenesis of low back and leg pain.