| 苦参碱对大鼠实验性肝纤维化的影响 |
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| 引用本文： | 陈伟忠,张俊平,许青,胡振林,谢渭芬,张兴荣,马述春,胡和平,张贤康.苦参碱对大鼠实验性肝纤维化的影响[J].第二军医大学学报,1996(5). |
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| 作者姓名： | 陈伟忠 张俊平 许青 胡振林 谢渭芬 张兴荣 马述春 胡和平 张贤康 |
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| 作者单位： | 第二军医大学长征医院消化内科，第二军医大学药学院中西药研究室 |
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| 摘 要： | 目的：研究苦参碱对肝纤维化的防治作用及其机理。方法：应用四氯化碳诱导大鼠实验性肝纤维化，并以苦参碱防治。观察了３，６，１２周对照组、模型组、治疗组的血清丙氨酸转移酶（ＡＬＴ）、透明质酸（ＨＡ）、肝组织羟脯氨酸（ＨｙＰ）含量以及肝脏病理变化。结果：苦参碱５０ｍｇ／ｋｇ和１００ｍｇ／ｋｇ均能显著减轻肝细胞变性、坏死及纤维组织的形成，同时能降低不同实验阶段血清ＡＬＴ（Ｐ＜０．０１）、ＨＡ（Ｐ＜０．０１）以及肝组织中Ｈｙｐ含量（Ｐ＜０．０５）。结论：苦参碱有防治四氯化碳诱发的肝纤维化的作用。
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| 关 键 词： | 苦参碱，肝纤维化，大鼠 |
Effects of matrine on rat liver fibrosis |
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| Chen Weizhong, Zhang Junping,Xu Qing, Hu Zhenlin, Xie Weifen,ZhangXingrong,Ma Shuchun,Hu Heping,Zhang Xiankang.Effects of matrine on rat liver fibrosis[J].Academic Journal of Second Military Medical University,1996(5). |
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| Authors: | Chen Weizhong Zhang Junping Xu Qing Hu Zhenlin Xie Weifen ZhangXingrong Ma Shuchun Hu Heping Zhang Xiankang |
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| Abstract: | Objective: To study the antifibrogenetic effect of matrine.Methods:The experimental liver fibrosis induced by tetrachloride in rats were treated with matrine.Serum alamine aminotransferase (ALT) .hyaluronate (HA).and hydroxyproline (HyP) and pathological change in liver tissue were observed. Data were expressed as.Significance of statistical differences was assessed by paired t-text.Results:Elevated serum ALT,HA and HyP in liver tissue were markedly decreased,and liver necrosis and fibrogenesis were also significantly alleviated when tetrachloride- treated rats were intragastrically given matrine 50 mg/kg and 100 mg/kg once a day for the indicated time. Conclusion:Matrine has an antifibrogenetic action. |
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| Keywords: | matrine liver fibrosis rats |
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