| Toll作用蛋白(Tollip)在急性阑尾炎时的表达 |
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| 引用本文： | 徐发良.Toll作用蛋白(Tollip)在急性阑尾炎时的表达[J].第二军医大学学报,2010,31(1):87-90. |
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| 作者姓名： | 徐发良 |
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| 作者单位： | 重庆市肿瘤医院腹部外科,重庆市肿瘤研究所,重庆,400030 |
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| 摘 要： | 目的分析Toll作用蛋白(Toll-interacting protein,Tollip)在阑尾组织的表达及其在急性炎症中的意义。方法选择急性阑尾炎33例,以无炎症阑尾6例作对照(阑尾组织无炎性病理改变);阑尾切除术前1h检测脉搏、体温(BT)、白细胞(WBC)计数和中性粒细胞(NEUT)计数;阑尾标本经H-E染色和病理检查确诊后分为4组(A组无炎症,B组单纯性炎症、C组化脓性炎症、D组坏疽性炎症),采用免疫组化染色和数字图像分析法对Tollip的蛋白表达进行定性、定位和半定量分析,并统计分析Tollip与脉搏、BT、WBC及NEUT的相关性。结果按照病理类型分组,组间BT、WBC和NEUT存在显著差异(P<0.05);中性粒细胞低表达或不表达Tollip,Tollip主要表达于阑尾黏膜上皮和腺上皮细胞;阑尾从无炎症状态到发生单纯性炎症、化脓性炎症以及坏疽性炎症的过程中,Tollip的表达逐步升高,并与WBC显著相关(P<0.05)。结论在急性阑尾炎发生和发展过程中,阑尾组织局部的Tollip表达上调并与WBC升高等炎症全身反应密切相关。
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| 关 键 词： | 阑尾炎 Tollip 基因表达 炎症反应 免疫组织化学 |
| 收稿时间： | 2009/8/28 0:00:00 |
| 修稿时间： | 2009/12/17 0:00:00 |
Expression of Toll-interacting protein (Tollip) in appendix during acute appendicitis |
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| XU Fa-liang.Expression of Toll-interacting protein (Tollip) in appendix during acute appendicitis[J].Academic Journal of Second Military Medical University,2010,31(1):87-90. |
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| Authors: | XU Fa-liang |
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| Institution: | XU Fa-liang Department of Abdominal Surgery,Cancer Hospital of Chongqing,Chongqing Cancer Institute,Chongqing 400030,China |
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| Abstract: | Objective To observe the expression of Toll-interacting protein ( Tollip) in appendix and analyze its significance during acute inflammation. Methods Thirty-three patients with acute appendicitis were included in the present study and 6 subjects with non-inflammatory appendixes were taken as controls ( without inflammatory changes). The pulse rate,body temperature ( BT) ,white blood cell ( WBC) count and neutrophil ( NEUT) count were observed one hour before appendectomy. Based on H-E staining and pathologi... |
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| Keywords: | appendicitis Tollip gene expression inflammatory response immunohistochemistry |
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