金匮肾气丸治疗牙周病的临床疗效观察

目的初步评价金匮肾气丸治疗牙周病的临床疗效。方法选取120例牙周病病例，经中医辩证诊断为肾气亏损；随机分为两组各60例，A组采用中医辨证治疗，进行一次全口龈上、龈下超声波洁治后，先以金匮肾气丸汤剂每日1剂，2次/d，煎服2周，后以丸剂桂附地黄丸口服，每次8丸，2次/d，2周为一疗程，3个疗程结束后统计疗效。B组单纯进行一次全口龈上、龈下超声波洁治。疗效测定分别于治疗前（基线）、疗程结束后4周、12周复诊分别检查记录每个受检位点的①菌斑指数（plaque index，PLI）、②龈沟出血指数（sulcus bleeding index，SBI）、③牙周探诊深度（periodontal probing depth，PD）、④附着丧失（attachment loss，AL）、⑤探诊出血（bleeding onp robin，BOP）牙周检测临床指标。结果 A组疗程结束后4周、12周的PLI、SBI、PD、AL、BOP疗效测定分别与治疗前（基线）对比明显改善，差异有统计学意义；B组差异无统计学意义；A组与B组比较，差异有统计学意义。结论金匮肾气丸治疗牙周病短期疗效良好，但长期疗效仍有待观察研究。

To observe the clinical effect of Jinkui Shenqi PiU in the treatment of periodontal disease

Objective Clinical curative effect evaluation of Jinkui Shenqi Pill in the treatment of periodontal disease. Methods 120 patients with periodontal disease, the Chinese medicine dialectical diagnosis of Shenqi losses; 120 patients were randomly divided into two groups, A group of 60 cases treated by TCM, a full supragingival, subgingival ultrasonic scaling, removal of plaque, first in Jinkui Shenqi Pill decoction, daily 1 agent, 2 times/day, 2 weeks after taking decoction, pill Guifu Dihuang Pill, 8 pills each time, 2 times/d, 2 weeks as a course of treatment, the curative effect after the 3 course of treatment. Group B received a full supragingival, subgingival ultrasonic scaling. Curative effect were measured before treatment（baseline）, after treatment for 4 weeks, 12 weeks were examined by recording each of PLI, SBI, PD, AL, and BOP clinical indicators of periodontal detection. Results In group A after treatment for 4 weeks, 12 weeks of PLI, SBI, PD, AL, BOP were measured before and after treatment efficacy（baseline） contrast is improved obviously, the difference was statistically significant; there was no significant difference in B group; A group compared with B group, the difference has not very significant. Conclusion Jinkui Shenqi Pill in the treatment of periodontal disease to get short-term clinical curative effect good, but the long-term efficacy remains to be seen on.