| 乳腺浸润性导管癌中ER、PR、C-erbB-2和p53的表达及临床意义 |
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| 引用本文： | 杨继洲,何惠华,戴一菲.乳腺浸润性导管癌中ER、PR、C-erbB-2和p53的表达及临床意义[J].中国医疗前沿,2008,3(8). |
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| 作者姓名： | 杨继洲 何惠华 戴一菲 |
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| 作者单位： | 孝感市中心医院病理科 |
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| 摘 要： | 目的联合检测ER、PR、抑癌基因p53和癌基因C-erbB-2在乳腺浸润性导管癌中的表达情况,来探讨与浸润性导管癌淋巴结转移及预后之间的联系。方法采用免疫组化S-P法分别检测242例乳腺浸润性导管癌ER、PR、C-erbB-2和p53的表达。结果242例乳腺浸润性导管癌中ER、PR、C-erbB-2和p53的阳性表达率分别为69.42%,63.22%,46.28%,34.30%。ER、PR基因表达与有无淋巴结转移及病理组织学分级有关;C-erbB-2、p53阳性表达率与有无淋巴结转移及病理组织学分级有关(p<0.05),C-erbB-2、p53共同阳性表达与淋巴结转移有关。结论联合检测乳腺浸润性导管癌ER、PR、C-erbB-2和p53基因表达对预测乳腺浸润性导管癌淋巴结转移及判断预后有重要意义。
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| 关 键 词： | 乳腺浸润性导管癌 雌激素受体 孕激素受体 抑癌基因p53 癌基因 C-erbB-2 淋巴结转移 |
Clinical significance of ER、PR、C-erbB-2 and p53 expression in breast infitrating ductal carcinoma |
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| Yang Ji Zhou,He Hui Hua,Dai Yi Fei.Clinical significance of ER、PR、C-erbB-2 and p53 expression in breast infitrating ductal carcinoma[J].China Healthcare Innovation,2008,3(8). |
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| Authors: | Yang Ji Zhou He Hui Hua Dai Yi Fei |
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| Institution: | Department of Pathology; Xiaogan Central Hospital; Hubei 432100 China; |
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| Abstract: | Objective To study the clinical significance of ER, PR, C-erbB-2 and p53 expression in breast infitrating ductal carcinoma tissues. Methods Using immunohistochemistry technique(S-P)to detect the espression of ER, PR, C-erbB-2 and p53 in 242 cases of breast infitrating ductal carcinoma.Results The positive expression rates of ER, PR, C-erbB-2 and p53 were 69.42%, 63.22%, 46.28% and 34.30% respectively in breast infitrating ductal carcinoma specimens; there existed correlation between the positive expression ... |
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| Keywords: | Breast infiltrating ductal carcinoma ER PR C-erbB-2 p53 Lymphatic metastasis |
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