再生障碍性贫血动物模型研究进展

再生障碍性贫血(aplastic anemia,AA),是一组造血组织功能衰竭综合征,其发病机制与造血干细胞损伤、造血微环境受损、免疫功能异常特别是 T 细胞功能亢进和细胞毒性 T 淋巴细胞直接杀伤骨髓造血干细胞以及淋巴因子介导的造血干细胞过度凋亡引起的骨髓造血细胞减少和功能衰竭有关.从病因方面AA可分为先天性和后天性...

Advances in animal models of aplastic anemia

Aplastic anemia (AA) is a group of hematopoietic tissue failure syndrome.Its pathogenesis is related to hematopoietic stem cell injury, hematopoietic microenvironment impairment, abnormal immune function, especially T cell hyperfunction and cytotoxic T lymphocytes directly killing marrow hematopoietic stem cells, and bone marrow hematopoietic cell reduction and function failure caused by lymphokine-mediated hematopoietic stem cell excessive apoptosis.In clinical practice, congenital aplastic anemia and acquired aplastic anemia often occur, among which, congenital aplastic anemia is also known as Fanconi anemia (FA). Studies have shown that,This type of anemia is associated with high sensitivity of DNA double strand to cross-linkers and chromosome damage caused mainly by mutations in 22 different genes, commonly referred to as FANC genes. Modeling methods commonly used in the laboratory include G2 phase ionizing radiation and FANC gene knockout.The animal models of acquired aplastic anemia can be modeled by different methods based on different mechanisms.In this paper, we will introduce and summarize the methods of making the most commonly used animal models of laboratory AA.