2型糖尿病大血管病变患者瘦素和脂联素浓度变化及意义

目的：探讨2型糖尿病合并大血管病变患者瘦素、脂联素浓度的变化及其临床意义。方法：采用ELISA法测定比较2型糖尿病合并大血管病变组47例和2型糖尿病无合并大血管病变组33例患者的瘦素、脂联素水平，其中大血管病变组分为3个亚组。结果：大血管病变组瘦素水平显著高于无大血管病变组（P〈0．01）：脂联素水平显著低于无大血管病变组（P〈0．01）。不同部位大血管病变组间瘦素、脂联素水平差异无显著性。结论：血清瘦素水平增高、脂联素水平降低为2型糖尿病合并大血管病变的独立危险因素，血清瘦素水平增高、脂联素水平降低在2型糖尿病大血管病变从无到有的发生过程中起了重要作用。

Clinical signifcance and changes of leptin and adiponectin concentration in type 2 diabetic patients with macrovascular pathological changes

Objective:To investigate the clinical significance and changes of leptin and adiponectin concentration in type 2 cliabetes patients with macrovascular pathological changes.Methods:80 patients with type 2 diabetes mellitus were divided into two groups:one group included 47 patients with macrovascular pathological changes and another group included 33 patients without macrovascular pathologi-cal changes.The serum concentration of leptin and adiponectin was detected in the two groups.Results:The leptin concentration was higher statistically in group with macrovascular pathological changes than that in the other on(eP<0.01).However,the adiponectin concentration was lower statistically in group with macrovascular pathological changes than that in the other one( P<0.01).The serum concentration of leptin and adiponectin had no significant difference among the three subgroups of macrovascular pathological changes.Conclusion:High leptin concentration and low adiponectin concentration are two independent risk factors in type 2 diabetic patients with macrovascular pathological changes,and they play an important role in progressing the macrovascular pathological changes in type 2 diabetic patients.