脑缺血预处理对离体大鼠心脏再灌注损伤的影响

目的:研究脑缺血预处理对离体大鼠心脏再灌注损伤有无保护作用.方法:采用离体大鼠缺血再灌注模型,22只雄性SD大鼠随机分成单纯缺血复灌组(IR),经典预处理组(IPC),脑缺血预处理组(BPC),在Langendorff装置上对大鼠离体心脏进行灌流.比较分析各组左室舒张末期压力(LVEDP),左室发展压(LVDP)和心肌梗死面积.结果与I/R组比较,脑缺血预处理能明显增加复灌各个时间点的LVDP恢复率,抑制LVEDP的增加(P＜0.01),明显减小心肌梗死范围;且与经典预处理组比较差异无显著性.结论:脑缺血预处理对离体大鼠的心脏有保护作用,其保护程度与经典预处理的保护作用相似.

Protective effect of brain ischemia preconditioning on myocardium from ischemia-reperfusion injury

Objective: To investigate the protective effect of brain ischemia preconditioning on isolated rat heart of ischeraia-reperfusion injury. Methods: Langendorff reperfusion models of cardiac ischemic-reperfusion was established. Twenty-two male SD rats were randomly divided into three groups: ischemic/reperfusion (I/R) group, classic ischemia preconditioning (IPC) group and brain ischemia preconditioning (BPC) group. Left ventricular end-diastolic pressure (LVEDP), the recovery of left ventricular developed pressure (LVDP%), and myocardial infarct size were analyses. Results: In BPC group, LVDP% was significantly improved, and LVEDP decreased, infarct size reduced, compared with the I/R group. Conclusion: Brain ischemia preconditioning has a protective effect on myocardium from ischemia-reperfusion injury. The protective effectiveness is similar to that of heart ischemic preconditioning.