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妊娠期肝内胆汁淤积症动物模型的复制
引用本文:龙子江,黄和平,张文家,王桐生,李明山.妊娠期肝内胆汁淤积症动物模型的复制[J].安徽中医学院学报,2004,23(1):38-39.
作者姓名:龙子江  黄和平  张文家  王桐生  李明山
作者单位:1. 安徽中医学院药理教研室,安徽,合肥,230038
2. 安徽省合肥市第三人民医院
基金项目:安徽省教育厅自然科学基金
摘    要:目的:研究妊娠期肝内胆汁淤积症动物模型.方法:取体质量25~30 g成年小鼠,按雌雄2∶1合笼,以有阴道栓为小鼠怀孕的第1 d,然后取怀孕小鼠20只分为2组,一组为妊娠对照组,另一组为实验组,另取10只正常小鼠作为正常对照组.实验组从其妊娠第12 d开始肌肉注射苯甲酸雌二醇,妊娠对照组与正常对照组均注射等容量9.0 g/L氯化钠注射液.结果:实验组血清中的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、总胆汁酸(TBA)均较妊娠对照组升高(P<0.05).结论:采用苯甲酸雌二醇可复制怀孕小鼠肝内胆汁淤积症动物模型.

关 键 词:动物模型  妊娠期肝内胆汁淤积症  苯甲酸雌二醇
文章编号:1000-2219(2004)01-0038-03
修稿时间:2003年9月9日

Duplicate the Model of Intrahepatic Cholestasis in Pregnant Mice
LONG Zi jiang,HUANG He ping,ZHANG Wen ji,WANG Tong sheng,LI Ming shan.Duplicate the Model of Intrahepatic Cholestasis in Pregnant Mice[J].Journal of Anhui Traditional Chinese Medical College,2004,23(1):38-39.
Authors:LONG Zi jiang  HUANG He ping  ZHANG Wen ji  WANG Tong sheng  LI Ming shan
Abstract:Objective:To study the model of intrahepatic cholestasis in pregnant mice.Method: The weight of these adult mice was between 25 g and 30g.There were two female and one male mice in every cage. The day that pessary was found was the first day that mice were pregnant.Twenty pregnant mice were divided into normal pregnant group and experimental group.Another ten normal female mice were used as control group.Mie in experimental group were injected estradiol benzoate from 12th day when mice were pregnant.Mice in both pregnant group and normal control group were injected equal volume of normal saline.Result:The serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total biliary acid increased significantly in the experimental group,compared with those of pregnant group (P<0.05).Conclusion:the animal model of intrahepatic cholestasis in pregnant mice can be made by injecting estradiol benzoate.
Keywords:Animal model Intrahepatic cholestasis during pregnancy  Estradiol benzoate
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