肝纤康防治肝纤维化的实验研究

目的：观察肝纤康对小鼠实验性肝纤维化的防治作用及其机制。方法：采用四氯化碳（CCl4）复制小鼠肝纤维化模型，同时予以肝纤康灌胃治疗，观察小鼠血清丙氨酸氨基转移酶（ALT）、天门冬酸氨基转移酶（AST）、白蛋白（Alb）、肝组织羟脯氨酸（Hyp）含量及肝组织病理改变。结果：模型组小鼠ALT、AST、Hyp显升高，Alb显降低，肝纤维化病变明显；给药组ALT、AST、Hyp明显降低，Alb明显升高，与模型且比较差异有显性（P＜0．01或P＜0．05）；并能明显减轻小鼠肝细胞损害和胶原纤维增生的程度。结论：肝纤康有较好的保护肝功能和防治肝纤维化作用。

EXPERIMENTAL STUDY ON TREATMENT OF LIVER FIBROSIS WITH GANXIANKANG DECOCTION

Objective:To study the pharmacological actions of Ganxiankang decoction on experimental liver fibrosis in mice. Method: The animal model of liver fibrosis in mice was induced by carbon tetrachloride.The Ganxiankang decoction was administered by intragastric injection. The levels of alanine aminotransferase (ALT),aspartate aminotransferase(AST),albumin(Alb) in the serum and hydroxyproline(Hyp) in the liver tissue and the pathogenic changes of liver tissue were observed. Result:In model group,the levels of ALT,AST,Hyp were significantly increased,while Alb was significantly decreased and liver fibrosis was obviously observed. After treated with Ganxiankang decoction,the levels of ALT,AST,Hyp were decreased significantly and Alb was markedly increased as compared with those of model group(P<0.05 or P<0.01) ,and the injury of liver cells and the proliferation degree of collagenous fibers were obviously decreased. Conclusion: Ganxiankang can protect liver function and has preventive effect on liver fibrosis.