舒心汤治疗舒张性心力衰竭30例临床研究

目的观察舒心汤治疗舒张性心力衰竭(diastolic heart failure,DHF)患者的临床疗效,探究其作用机制。方法将60例DHF患者随机分为对照组(30例)和治疗组(30例),对照组接受常规西药治疗,治疗组在常规西药治疗的基础上加用舒心汤治疗,疗程2周。观察并比较两组心功能疗效;治疗前后分别测定两组患者超声心动图E/A比值,以及血清脑钠肽(brain natriuretic peptide,BNP)、一氧化氮(nitric oxide,NO)、内皮素-1(endothelin-1,ET-1)水平。结果两组心功能疗效比较,差异无统计学意义(P0.05);两组治疗后E/A比值和血清NO水平均较治疗前显著升高(P0.01),血清BNP和ET-1水平均显著降低(P0.01),治疗组在升高E/A比值和血清NO水平方面显著优于对照组(P0.01)。结论舒心汤联合常规西药可以改善DHF患者的心功能,在升高超声心动图E/A比值和血清NO水平方面较常规西药具有明显优势。

Clinical Efficacy of Shuxing Decoction in Treatment of Diastolic Heart Failure: A Report of 30 Cases

Objective To observe the clinical efficacy of Shuxing Decoction in the treatment of diastolic heart failure (DHF) and to investigate its action mechanism. Methods Sixty patients with DHF were randomly divided into control group (n =30) and treatment group (n=30).The control group received conventional Western medicine treatment, while the treatment group received Shuxing Decoction in addition to conventional Western medicine treatment. The course of treatment was two weeks. The two groups were compared in terms of improvement in cardiac function after treatment. Before and after treatment, E/A ratio, as calculated by echocardiography, and serum levels of brain natriuretic peptide (BNP), nitric oxide (NO), and endothelin-1 (ET-1) were determined. Results There was no significant difference in treatment outcome between the two groups (P>0.05). After treatment, both groups showed significant increases in E/A ratio and serum NO level (P<0.01) and significant decreases in serum BNP and ET-1 levels (P<0.01).The treatment group had significantly higher increases in E/A ratio and serum NO level than the control group (P <0.01). Conclusion Shuxin Decoction combined with conventional Western medicine treatment can improve cardiac function in DHF patients and is superior to conventional Western medicine treatment in increasing E/A ratio and serum NO level.