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养肝益水颗粒对原发性高血压早期肾损害患者血清NO、hs—CRP的影响
引用本文:李艳,戴小华,杨帆.养肝益水颗粒对原发性高血压早期肾损害患者血清NO、hs—CRP的影响[J].安徽中医学院学报,2009,28(2):30-31.
作者姓名:李艳  戴小华  杨帆
作者单位:安徽中医学院第一附属医院心内科,安徽,合肥230031
摘    要:目的:观察养肝益水颗粒对原发性高血压早期肾损害患者一氧化氮(nitricoxide,NO)、超敏C-反应蛋白(high sensitive C—reactive protein,hs-CRP)的影响。方法:将70例原发性高血压早期肾损害患者随机分为治疗组和对照组各35例,两组均常规服用降压药,治疗组加用养肝益水颗粒口服,分别观察两组治疗前后血清NO和hs-CRP水平的变化。结果:两组治疗后hs—CRP水平较治疗前明显降低,NO水平显著升高(P〈0.05)。治疗组治疗后上述各指标较对照组变化更显著(P〈0.01)。结论:养肝益水颗粒可能通过改善血管内皮功能、抑制炎性反应而改善患者预后。

关 键 词:原发性高血压  早期肾损害  超敏C-反应蛋白  一氧化氮  养肝益水颗粒

Effects of Yanggan Yishui Granules on the Serum Levels of Nitric Oxide and High Sensitive C-reactive Protein in Essential Hypertension Patients with Early Renal Damage
LI Yan,DAI Xiao-hu,YANG Fan.Effects of Yanggan Yishui Granules on the Serum Levels of Nitric Oxide and High Sensitive C-reactive Protein in Essential Hypertension Patients with Early Renal Damage[J].Journal of Anhui Traditional Chinese Medical College,2009,28(2):30-31.
Authors:LI Yan  DAI Xiao-hu  YANG Fan
Institution:(Department of Cardiovascular Diseases, the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine, Anhui Hefei 230031, China)
Abstract:Objective:To observe the effects of YangganYishui (YGYS) Granules on the serum levels of nitric oxide (NO) and high sensitive C-reactive protein (hs-CRP) in essential hypertension (EH) patients with early renal damage. Methods:Seventy EH patients with early renal damage were randomly divided into treatment group (n=35) and controt group (n=35). Patients in two groups conventionally took hypotensive drugs; additionally, patients in treatment group orally took YGYS Granules. The serum levels of NO and hs-CRP in two groups were observed before and after the treatment. Results: After the treatment, the serum level of hs-CRP in two groups was significantly decreased, while the level of NO was significantly increased compared with that before the treatment (P〈0.05). After the treatment, all the above-mentioned indexes in treatment group were significantly improved compared with those in control group. Conclusion: YGYS Granules might improve the prognosis of EH patients by improving the function of blood vessel epithelium, inhibiting the inflammatory reaction.
Keywords:Essential hypertension  Early renal damage  High sensitive C-reactive protein  Nitric oxide  YangganYishui Granules
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