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痛风康对酵母膏致高尿酸血症大鼠尿酸代谢及黄嘌呤氧化酶活性的影响
引用本文:程芳,戴敏,胡翠云,宣自华.痛风康对酵母膏致高尿酸血症大鼠尿酸代谢及黄嘌呤氧化酶活性的影响[J].安徽中医学院学报,2011,30(4):55-58.
作者姓名:程芳  戴敏  胡翠云  宣自华
作者单位:程芳,胡翠云(安徽中医学院药学院,安徽,合肥,230031);戴敏,宣自华(安徽中医学院药学院,安徽,合肥,230031;现代中药安徽省重点实验室,安徽,合肥,230031)
摘    要:目的观察痛风康对高尿酸血症大鼠的尿酸(uric acid,UA)代谢及黄嘌呤氧化酶(xanthine oxi-dase,XO)活性的影响。方法将60只SD大鼠随机分为正常对照组,模型组,别嘌呤醇组,痛风康高(460mg/kg)、中(230 mg/kg)、低(115 mg/kg)剂量组,灌胃给药;采用酵母膏致高尿酸血症模型;检测各组大鼠血UA水平和血清XO活性,并测定大鼠24 h尿量及尿UA水平,计算24 h UA排泄量。结果酵母膏能明显升高大鼠血UA水平,降低尿量和24 h UA排泄量。痛风康高、中剂量组大鼠血清UA水平显著降低;痛风康中、低剂量组大鼠24 h UA排泄量均明显增加。痛风康各剂量组血清XO活性均明显降低,尿量显著增加。结论痛风康能明显降低高尿酸血症大鼠血UA水平及促进UA排泄,该作用可能与其抑制XO活性和利尿作用有关。

关 键 词:高尿酸血症  尿酸  痛风康  酵母膏  黄嘌呤氧化酶

Effects of Tongfeng Kang Ethanol Extracts on Metabolism of Uric Acid and Activities of Xanthine Oxidase in Rats with Yeast Extracts Induced Hyperuricemia
CHENG Fang,DAI Min,HU Cui-yun,XUAN Zi-hua,.Effects of Tongfeng Kang Ethanol Extracts on Metabolism of Uric Acid and Activities of Xanthine Oxidase in Rats with Yeast Extracts Induced Hyperuricemia[J].Journal of Anhui Traditional Chinese Medical College,2011,30(4):55-58.
Authors:CHENG Fang  DAI Min  HU Cui-yun  XUAN Zi-hua  
Institution:(1.School of Pharmacy,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China;2.Anhui Key Laboratory for Modern Materia Medica,Anhui Hefei 230031,China)
Abstract:Objective To observe the effects of Tongfeng Kang ethanol extracts,a preparation from a proved recipe of a famous traditional Chinese medicine physician in the treatment of gout,on the metabolism of uric acid(UA) and the activities of xanthine oxidase(XO) in rats with hyperuricemia.Methods Sixty male SD rats were averagely randomized into control group,model group,allopurinol treated group,and high(460 mg/kg)-,middle(230 mg/kg)-and low-dose(115 mg/kg) of Tongfeng Kang treated groups.The corresponding drugs were administered by intragastric injection.The rat model of hyperuricemia was induced by orally administering yeast extracts.Some indicators were assayed and compared among the groups,including the serum and urine levels of UA,the serum activities of XO,the volume of urine during 24 hours,as well as the excretion of UA from urine during 24 hours.Results Yeast extracts could significantly increase the serum levels of UA,reduce the volume of urine,and the excretionof UA from urine during 24 hours.High-and middle-dose of Tongfeng Kang could significantly reduce the serum levels of UA,and middle-and low-dose of Tongfeng Kang could obviously promote the excretion of UA from urine during 24 hours.The serum activities of XO were significantly decreased,and the volume of urine during 24 hours significantly decreased in high-,middle-and low-dose of Tongfeng Kang treated groups compared with those in model group.Conclusion Tongfeng Kang can obviously reduce the serum levels of UA,and promote the excretion of UA from urine in rats with hyperuricemia,the mechanism of which might be related to its inhibiting the activities of XO,and its diuretic effects.
Keywords:hyperuricemia  uric acid  Tongfeng Kang  yeast extracts  xanthine oxidase
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