| 葛根素及其衍生物在大鼠体内的药代动力学研究 |
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| 引用本文： | 郭东艳,杨大坚,陈士林.葛根素及其衍生物在大鼠体内的药代动力学研究[J].陕西中医学院学报,2008,31(1):52-54. |
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| 作者姓名： | 郭东艳 杨大坚 陈士林 |
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| 作者单位： | 1. 陕西中医学院药学系,陕西,咸阳,712046;香港理工大学,香港,九龙
2. 香港理工大学,香港,九龙 |
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| 摘 要： | 目的比较葛根素与其衍生物在大鼠体内的生物利用度。方法大鼠股静脉取血，HPLC法测定血清中葛根素及其衍生物的血药浓度，应用3P97药动学统计软件对血药浓度数据拟合。结果葛根素、4ae、5ac、6ae的体内过程均符合二室开放模型。结论葛根素衍生物4ae能明显提高大鼠体内的生物利用度。
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| 关 键 词： | 葛根素 衍生物 药物动力学 高效液相 |
| 文章编号： | 1002-168X（2008）01-0052-03 |
| 收稿时间： | 2007-11-07 |
| 修稿时间： | 2007年11月7日 |
Pharmacokinetic Investigation of Pur and derivatives in rats |
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| Guo Dongyan,Yang Dajian,Chen Shilin.Pharmacokinetic Investigation of Pur and derivatives in rats[J].Journal of Shaanxi College of Traditional Chinese Medicine,2008,31(1):52-54. |
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| Authors: | Guo Dongyan Yang Dajian Chen Shilin |
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| Institution: | Guo Dongyan, Yang Dajian , Chen Shilin (1. Shaanxi College of traditional Chinese medicine, xianyang 712046 China; 2. The Hong Kong Polytechnic University,Hung Horn Hong Kong) |
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| Abstract: | Objective To study the pharmacokinetics of Pur and derivatives in rats. Method Blood was collected from femoral vein. The plasma concentration of the par and derivatives was determined by HPLC. The compartment model was calculated with 3P97 program and the pharmacokinetic parameters were compared with SPSS program. Result The par and derivatives could be fitted to two - compartment model in rats, Conclusion Derivatives - 4ac can obviously improve the bioavailability in rats. |
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| Keywords: | pur derivatives pharmacokinetics HPLC |
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