| 雄激素致不孕大鼠卵巢颗粒细胞凋亡及相关酶caspase-3的研究 |
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| 引用本文： | 马惠荣,杜惠兰,宋翠淼,杨秀芳,李国明.雄激素致不孕大鼠卵巢颗粒细胞凋亡及相关酶caspase-3的研究[J].陕西中医学院学报,2008,31(1):44-45. |
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| 作者姓名： | 马惠荣 杜惠兰 宋翠淼 杨秀芳 李国明 |
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| 作者单位： | 河北医科大学,河北,石家庄,050091 |
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| 基金项目： | 河北省卫生厅专项资助课题 |
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| 摘 要： | 目的探讨ASR卵巢颗粒细胞凋亡及凋亡相关酶caspase-3的表达。方法9日龄sD雌性大鼠颈背部皮下注射丙酸睾丸酮制造无排卵模型，3—4月龄时191道脱落细胞涂片选取动情前期处死大鼠，免疫组化法检测ASR卵巢颗粒细胞凋亡及相关酶caspase-3的表达。结果在ASR和正常大鼠均检测到颗粒细胞的凋亡及凋亡相关酶easpase-3的表达，模型组颗粒细胞凋亡及凋亡相关酶caspase-3的表达较强。结论卵巢颗粒细胞凋亡及凋亡相关酶caspase-3的表达增强导致了排卵障碍性不孕症的发生。
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| 关 键 词： | 雄激素不孕大鼠模型(ASR) 无排卵 卵巢颗粒细胞凋亡 实验研究 |
| 文章编号： | 1002-168X（2008）01-0044-02 |
| 收稿时间： | 2007-10-02 |
| 修稿时间： | 2007年10月2日 |
The expression of ovarian granular apoptosis and caspase -3 in ASR |
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| Ma Huirong,Du Huilan,Song Cuimiao,Yang Xiufang,Li Guoming.The expression of ovarian granular apoptosis and caspase -3 in ASR[J].Journal of Shaanxi College of Traditional Chinese Medicine,2008,31(1):44-45. |
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| Authors: | Ma Huirong Du Huilan Song Cuimiao Yang Xiufang Li Guoming |
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| Institution: | ( Hebei Medical Universily, Hebei Province, shijiazhuang 050091 ) |
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| Abstract: | Objective The purpose of this study was localize the expression of ovarian granular apoptosis and caspase - 3 in ASR to investigate the mechanism of anovulatory. Methods The anovulatory model was established by subcutaneous injection of testoserone propionate to SD female rats of 9 - day age, euthanized the rats of 3 - 4 month at the preoestrus, used the method of Immunocytochemistry to obsen, ed the expression and distribution of granular apoptosis and caspase - 3 in ASR and normal SD rats and compared the level of granular apoptosis and caspase - 3, Results Compared with normal group, There were stronger expression of granular apoptosis and caspase - 3 in ASR, Conclusions The stronger expression of granular apoptosis and caspase - 3 reduced the development of anovulatory in ASR. |
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| Keywords: | androgen induced sterile rats(ASR) anovulatory granular apoptosis of ovary experimental study |
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