沙利度胺联合小剂量MP方案化疗治疗老年多发性骨髓瘤的临床观察

目的]探讨沙利度胺联合小剂量MP方案化疗治疗老年多发性骨髓瘤的临床疗效及不良反应.方法]治疗组12例采用沙利度胺联合小剂量MP方案化疗,沙利度胺自化疗开始时给药,剂量200 mg/d分早、晚口服,以后每周加量50 mg,至300 mg～400 mg/d长期治疗.化疗方案采用小剂量MP方案,马法兰6 mg/d,第1～8天,泼尼松50 mg/d,第1～8天,15 d为一个疗程,连续治疗6个疗程.对照组14例,单纯应用小剂量MP方案化疗,方法及药物剂量均同治疗组.结果]治疗组部分缓解7例,进步3例,无效2例,总有效率83.33%,明显高于对照组(总有效率57.14%)(P＜0.01).治疗组各种疗效指标改善率均优于对照组(P＜0.01～P＜0.05).常见不良反应有便秘、腹胀、纳差、头晕、嗜睡及皮疹等,经调整药物剂量或对症治疗后,均可缓解,未出现严重不良反应.结论]沙利度胺联合小剂量MP方案化疗治疗老年多发性骨髓瘤具有副作用小、耐受性好、疗效明显等优点,对老年多发性骨髓瘤的治疗不失为一个好的治疗方法,值得推广应用.

Thalidomide combined small-dose MP plan in treatment of senile multiple myeloma (MM)

Objective] To explore the effectivity and adverse reaction of thalidomide combined small-dose MP plan in treatment of senile multiple myeloma(MM).Method] The experiment group were treated by thalidomide combined small-dose MP plan,the controlled group were treated by small-dose MP plan singlely.Result] Seven patiences of the experiment group had a partly recession,3 patiences for progress and 2 for ineffectivity.the total effective rate is 83.33%,which was obviously higher than that of the controlled group.there are common adverse reaction such as constipation,less eating,vertigo,somnolence and skin eruption.all mentioned could be handled by adjusting the medicine dose.Conclusion] Thalidomide combined small-dose MP plan has advantages of little side reaction,well endurity in treatment of senile multiple myeloma(MM).