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| 亚慢性砷暴露对雄性小鼠脑组织性基因Ddx3y和Uty表达的影响 | |
| 引用本文： | 洪 岩,朴丰源,刘 爽,崔 颖.亚慢性砷暴露对雄性小鼠脑组织性基因Ddx3y和Uty表达的影响[J].大连医科大学学报,2009,31(5):507-509. |
| 作者姓名： | 洪 岩 朴丰源 刘 爽 崔 颖 |
| 作者单位： | 1. 锦州市疾病预防控制中心,辽宁,锦州,121000;大连医科大学,劳动卫生与环境卫生学教研室,辽宁,大连,116044 2. 大连医科大学,劳动卫生与环境卫生学教研室,辽宁,大连,116044 3. 大连医科大学,中心实验室,辽宁,大连,116044 |
| 基金项目： | 国家自然科学基金，辽宁省教育厅项目 |
| 摘 要： | 目的]观察亚慢性砷暴露对雄性小鼠脑组织性基因Ddx3y和Uty表达的影响。方法]SPF级雄性小鼠30只,按体重将小鼠随机分为对照组、低剂量染砷组(1 mg/LAs2O3)和高剂量染砷组(4 mg/LAs2O3),每组10只。自然饮水使小鼠染砷,连续染毒60 d后取脑。RT-PCR法检测雄性小鼠脑组织性基因Ddx3y和Uty的mRNA表达变化。结果]与对照组比较,染砷组小鼠大脑髓质和小脑组织Ddx3y和Uty mRNA表达量明显增多,差异有显著性意义(P<0.05)。而大脑皮质性基因Ddx3y和Uty mRNA表达量明显减少,差异有显著性意义(P<0.05),尤其高剂量染砷组mRNA表达变化更明显。结论]亚慢性砷暴露可下调雄性小鼠脑皮质性基因Ddx3y和Uty的mR-NA表达,同时上调髓质和小脑性基因Ddx3y和Uty的mRNA表达。 |
| 关 键 词： | 三氧化二砷 脑 性基因 雄性生殖毒性 |
Influence of subchronic exposure to arsenic on expressions of Ddx3y and Uty in brain of male mice |
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| HONG Yan,PIAO Feng-yuan,LIU Shuang and CUI Ying.Influence of subchronic exposure to arsenic on expressions of Ddx3y and Uty in brain of male mice[J].Journal of Dalian Medical University,2009,31(5):507-509. | |
| Authors: | HONG Yan PIAO Feng-yuan LIU Shuang and CUI Ying |
| Institution: | HONG Yan 1,2,PIAO Feng-yuan2,LIU Shuang 2,CUI Ying3(1.Jinzhou Center for Disease Control , Prevention,Jinzhou 121000,China,2.Department of Occupatinal , Environmental Health,Dalian Medical University,Dalian 116044,3.Center of Libratory,China) |
| Abstract: | Objective] To examine the influence of subchronic exposure to arsenic(As) on expressions of Ddx3y and Uty in the brain of mice.Methods] Thirty male mice were divided into 3 groups of 10 each.The mice in group 1 received drinking water alone(control),and group 2 or 3 received 1 or 4 mg/L arsenic trioxide.On the 60th day after As exposure,mice were decapitated and their brains were removed.Expressions of Ddx3y and Uty were examined in the different area ofbrain of mice exposed to As by RT-PCR.Results] Comp... |
| Keywords: | As2O3 brain sexogene male reproductive toxicity |
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