|
|||||
|
|
| 抑癌基因 PTEN 与肿瘤 | |
| 引用本文： | 邹向阳,张秀蓉,姜 涛,张翠丽,李 杨,韩 娀.抑癌基因 PTEN 与肿瘤[J].大连医科大学学报,2006,28(1):67-70. |
| 作者姓名： | 邹向阳 张秀蓉 姜 涛 张翠丽 李 杨 韩 娀 |
| 作者单位： | 1. 大连医科大学,生物技术专业,辽宁,大连116027 2. 大连市妇产医院,辽宁,大连,116033 3. 吉林大学,基础医学院,吉林,长春,130021 4. 大连医科大学,基础医学03级长年制,辽宁,大连,116027 |
| 摘 要： | PTEN基因是迄今为止发现的第一个具有双特异性磷酸酶（DPs）活性的抑癌基因，该基因在细胞的生长、增殖、迁移和细胞凋亡中具有重要的生物学功能。PTEN基因的突变、缺失或转录水平降低常见于多种原发性恶性肿瘤，如脑胶质瘤、乳腺癌、肾癌、子宫内膜癌和恶性黑色素瘤，表明PTEN基因与肿瘤的形成与发展密切相关。 |
| 关 键 词： | 抑癌基因 肿瘤 |
| 文章编号： | 1671-7295(2006)01-0067-04 |
| 修稿时间： | 2005年10月11 |
Phosphatase and tension homology deleted from chromosome ten and tumor |
|
| ZOU Xiang-yang,ZHANG Xiu-rong,JIANG Tao,ZHANG Cui-li,LI Yang and HAN Song.Phosphatase and tension homology deleted from chromosome ten and tumor[J].Journal of Dalian Medical University,2006,28(1):67-70. | |
| Authors: | ZOU Xiang-yang ZHANG Xiu-rong JIANG Tao ZHANG Cui-li LI Yang and HAN Song |
| Abstract: | PTEN(phosphatase and tension homology deleted from chromosome ten) was the firstly defined tumor supprossor gene which product acted as phosphatase and shared extensive homology with cytoskeketal protein,mapping to human chromosome 10q23.3.Recently,many studies showed that there were several putative mechanisms relating to tumor suppression,such as inhibiting cell invasion and metastasis by dephosphorating FAK;inhibiting cell apoptosis and increasing cell growth by dephosphorating PIP3;restraining cell differentiation by inhibiting MAPK signal pathway.Mutation or abnormal expression of PTEN protein occurred commonly in multiple tumors and significantly correlates with tumorigenesis and progression of different malignancies.The article summarized the progress of researches about correlationship between PTEN and human tumor. |
| Keywords: | PTEN |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《大连医科大学学报》浏览原始摘要信息 | |
| 点击此处可从《大连医科大学学报》下载免费的PDF全文 | |