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雄黄诱导K562/ADM细胞凋亡的研究
引用本文:张晨,邹丽娟.雄黄诱导K562/ADM细胞凋亡的研究[J].大连医科大学学报,1999,21(1):11-13.
作者姓名:张晨  邹丽娟
作者单位:[1]解放军210医院血液病中医研究所 [2]大连医科大学基础医学院组胚学教研室
摘    要:探讨雄黄诱导多药耐药细胞K562/ADM细胞凋亡的能力,并初步探讨其分子机制,方法:采用荧光标记形态学观察,流式细胞仪进行DNA分析及测定细胞表面p-gp的表达。结果显示:雄黄能明显诱导K562/ADM细胞凋亡,且在48h后p-gp的表达下调。

关 键 词:雄黄  多药耐药  细胞凋亡  K562/ADM

Realgar induces apoptosis of K562/ADM cells
Zhang Chen,Huang Shilin,Zou Lijuan,et al Institute of Chinese Medical Hematology.Realgar induces apoptosis of K562/ADM cells[J].Journal of Dalian Medical University,1999,21(1):11-13.
Authors:Zhang Chen  Huang Shilin  Zou Lijuan  Institute of Chinese Medical Hematology
Institution:Zhang Chen,Huang Shilin,Zou Lijuan,et al Institute of Chinese Medical Hematology,The 210th Hospital
Abstract:To explore the apoptosis of tumor with multidrug resistance cells,the realgar was used,Sub-G1 and p-glycoprotein(p-gp) were detected by flow cytometry.Results showed that the sensitivity of K562/ADM to realgar was more than that of K562,and realgar was could down-regulate p-gp expression.
Keywords:realgar  multidrug resistance  apoptosis
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