| 粒细胞集落刺激因子对缺血再灌注损伤猪心肌凋亡和心肌纤维化的影响 |
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| 引用本文： | 梁 滨,周旭晨,黄榕翀,朱 皓,王俊杰,葛均波,邹云增.粒细胞集落刺激因子对缺血再灌注损伤猪心肌凋亡和心肌纤维化的影响[J].大连医科大学学报,2010,32(3):237-241. |
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| 作者姓名： | 梁 滨 周旭晨 黄榕翀 朱 皓 王俊杰 葛均波 邹云增 |
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| 作者单位： | 1. 大连医科大学附属第一医院,心内科,辽宁,大连,116011
2. 复旦大学附属中山医院,心内科,上海,200032 |
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| 基金项目： | 辽宁省教育厅高校科研计划项目 |
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| 摘 要： | 目的]观察粒细胞集落刺激因子(G-CSF)对缺血再灌注损伤猪心肌细胞凋亡和心肌纤维化的影响.方法] 建立急性缺血再灌注损伤小型猪动物模型,存活12只动物,随机分为对照组和G-CSF治疗组,每组6只.G-CSF治疗组按照5 μg/kg·d-1连续7 d皮下注射G-CSF,对照组给予同等量生理盐水.动物模型建成后及治疗后4周分别行冠状动脉造影、左室造影和201TI(铊)核素单光子放射计算机断层显像(SPECT)检查,记录左心室射血分数(LVEF)、左室运动不良节段数目以及心肌灌注损伤指数,并观察心肌凋亡和心肌纤维化情况.结果] 术后4周左室造影显示两组LVEF均改善,分别为(48.9±9.7)%与(52.4±10.1)%,尽管两组间比较差别无显著性意义(P>0.05),但G-CSF治疗可以改善左室局部运动不良节段数(29.4±12.7 vs 20.8±10.3,P<0.05).SPECT检查结果发现, G-CSF治疗可以减少心肌灌注缺损面积(26.9±11.8)% vs (13.2±10.1)%,P<0.05].而且,G-CSF治疗后心脏损伤区域局部心肌凋亡减少的数目比对照组多(-3.7±1.8)% vs (-1.5±2.0)%],心肌纤维化程度也明显低于对照组,差别有显著性意义(P<0.05).结论] G-CSF治疗可以通过降低心肌凋亡和心肌纤维化程度改善缺血再灌注损伤猪心脏功能.
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| 关 键 词： | 缺血再灌注 粒细胞集落刺激因子(G-CSF) 心脏功能 凋亡 心肌纤维化 |
Effect of hypodermic injection of granulocyte colony-stimulating factor on cardiomyocyte apoptosis and fibrosis after myocardial ischemia-reperfusion in swine |
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| LIANG Bin,ZHOU Xu-chen,HUANG Rong-chong,ZHU Hao,WANG Jun-jie,GE Jun-bo and ZOU Yun-zeng.Effect of hypodermic injection of granulocyte colony-stimulating factor on cardiomyocyte apoptosis and fibrosis after myocardial ischemia-reperfusion in swine[J].Journal of Dalian Medical University,2010,32(3):237-241. |
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| Authors: | LIANG Bin ZHOU Xu-chen HUANG Rong-chong ZHU Hao WANG Jun-jie GE Jun-bo and ZOU Yun-zeng |
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| Institution: | Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Department of Cardiology, the Third people's Hospital of Dalian, 116033 China;;Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;;Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;;Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;;Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;;Department of Cardiology, Zhongshan Hospital,Fudan University, Shanghai 200032, China;Department of Cardiology, Zhongshan Hospital,Fudan University, Shanghai 200032, China |
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| Abstract: | |
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| Keywords: | ischemia-reperfusion granulocyte colony-stimulating factor (G-CSF) heart function apoptosis myocardial fibrosis |
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