| 内镜技术治疗胃食管反流病的研究进展 |
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| 引用本文： | 宋顺喆,宫爱霞,郭世斌,陈浩,梁莉莉,包海东,孙康,孙颖,李宸宇.内镜技术治疗胃食管反流病的研究进展[J].大连医科大学学报,2019,41(5):448-453. |
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| 作者姓名： | 宋顺喆 宫爱霞 郭世斌 陈浩 梁莉莉 包海东 孙康 孙颖 李宸宇 |
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| 作者单位： | 大连医科大学附属第一医院内镜诊治中心,辽宁大连,116000 |
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| 基金项目： | 国家自然科学基金项目（81603424） |
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| 摘 要： | 胃食管反流病（gastroesophageal reflux disease，GERD）在亚洲的发病率逐年升高，严重影响患者的生活质量。质子泵抑制剂（proton pump inhibitor，PPI）一直被公认是治疗GERD的首选内科药物。约有30%的患者属于PPI难治性GERD，胃底折叠术是治疗GERD的首选术式，但手术创伤较大，术后并发症较多。随着内镜技术的发展，目前内镜下微创技术通过改善抗反流屏障成为治疗GERD的新思路。本文主要就内镜技术调节食管下段括约肌收缩功能，改善His角角度，修复胃食管阀瓣紧密性三个方面进行综述，主要包括射频消融技术，内镜下胃底折叠术，内镜下黏膜切除术。
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| 关 键 词： | 胃食管反流病 胃食管阀瓣 食管下段括约肌 内镜射频消融术 内镜下黏膜切除术 |
| 收稿时间： | 2019/1/1 0:00:00 |
| 修稿时间： | 2019/8/31 0:00:00 |
Advance in endoscopic technology for gastroesophageal reflux disease |
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| SONG Shunzhe,GONG Aixi,GUO Shibin,CHEN Hao,LIANG Lili,BAO Haidong,SUN Kang,SUN Ying and LI Chenyu.Advance in endoscopic technology for gastroesophageal reflux disease[J].Journal of Dalian Medical University,2019,41(5):448-453. |
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| Authors: | SONG Shunzhe GONG Aixi GUO Shibin CHEN Hao LIANG Lili BAO Haidong SUN Kang SUN Ying and LI Chenyu |
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| Institution: | Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China,Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China and Department of Endoscopy, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China |
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| Abstract: | Gastroesophageal reflux disease (GERD) interferes with the quality of patients'' lives and the morbidity are increasing in Asia. Proton pump inhibitor (PPI) is the mainstay of treatment for GERD. For PPI-refractory patients, fundoplication was considered as the principal surgery for GERD. Recently, with the development of endoscopic technology, Endoscopic surgery can repair the anti-reflux barrier with minimal invasiveness, which is considered as a new treatment for GERD. We mainly reviewed several endoscopic anti-reflux technology by strengthening the contractive function of lower esophageal sphincter, modifying the His angle and repairing the compactness of gastroesophageal flap valve, including radiofrequency ablation, endoscopic fundoplication and anti-reflux mucosectomy (ARMS). |
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| Keywords: | gastroesophageal reflux disease gastroesophageal flap valve lower esophageal sphincter endoscopic radiofrequency ablation anti-reflux mucosectomy |
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