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PGC-1α基因Gly482Ser多态性与2型糖尿病发病的相关性研究
引用本文:回圆敕,关玉峰,李 政,孙 崴,张 霞,张 萍,苏本利.PGC-1α基因Gly482Ser多态性与2型糖尿病发病的相关性研究[J].大连医科大学学报,2009,31(3):295-298.
作者姓名:回圆敕  关玉峰  李 政  孙 崴  张 霞  张 萍  苏本利
作者单位:1. 大连医科大学,附属第二医院,内分泌科,辽宁,大连,116027
2. 普兰店市中心医院,泌尿内科,辽宁,普兰店,116200
摘    要:目的]研究过氧化物酶体增殖物激活受体γ共活化物-1α(PGC-1α)G1y482Ser基因多态性与2型糖尿病发病的相关性。方法]选取大连居住的汉族人2型糖尿病病人(DM)140例和非糖尿病对照(NC)88人;用聚合酶链反应(PCR)-限制性内切酶技术检测PGC—1α G1y482Ser基因型。结果]DM组Ser/Ser基因型分与NC组比较差异有显著性意义(χ^2=10.969,P=0.004),按性别分层后男性DM组与NC组比较差异无显著性意义(χ^2=3.601,P=0.165),而女性DM组与NC组比较差异有显著性意义(χ^2=11.02,P=0.004)。在NC组和DM组,随Ser等危基因增加,空腹C肽和2h C肽呈逐渐降低趋势,但只有Ser/Ser与Gly/Gly两基因型之间相比差异有显著性意义(P〈0.05)。在NC组,各基因型之间的胰岛素抵抗之间比较差异无没有显著性意义(P〉0.05)。结论]PGC-1 Gly482Ser多态性可能与女性2型糖尿病的发病相关,Ser/Ser型携带者c肽水平更低。

关 键 词:2型糖尿病  过氧化物酶体增殖物激活受体γ辅激活因子-1α  遗传/多态性

Association of Peroxisome proliferator activated receptor-γ coactivator-1α(PGC-1α) Gly482Ser polymorphism with type 2 diabetes mellitus in Chinese women
HUI Yuan-Chi,GUAN Yu-Feng,LI Zheng,SUN Wei,ZHANG Xi,ZHANG Ping and SU Ben-li.Association of Peroxisome proliferator activated receptor-γ coactivator-1α(PGC-1α) Gly482Ser polymorphism with type 2 diabetes mellitus in Chinese women[J].Journal of Dalian Medical University,2009,31(3):295-298.
Authors:HUI Yuan-Chi  GUAN Yu-Feng  LI Zheng  SUN Wei  ZHANG Xi  ZHANG Ping and SU Ben-li
Institution:HUI Yuan-Chi1,GUAN Yu-Feng1,LI Zheng2,SUN Wei1,ZHANG Xia1,ZHANG Ping1,SU Ben-li1(1.Department of Clinical Endocrinology , Metabolism,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China,2.Central Hospital of Pul,ian,Pul,ian 116200,China)
Abstract:Objective] To study if PGC-1α Gly482Ser polymorphism is related to type 2 diabetes mellitus in Chinese.Methods] One hundred and forty type 2 diabetes(DM) and 98 non-diabetic controls(NC) were selected.Genotyping of PGC-1α Gly482Ser was determined with PCR amplification,followed by MspI digestion.Results] PGC-1α Ser/Ser genotype frequency in DM was significantly higher than that in NC(29% vs 12.5%,χ2=10.969,P=0.004).Upon stratification with sex Ser/Ser genotype was significantly higher in DM women than NC women(χ2=11.02,P=0.004),while it was not so in men.Both in NC and DM,fasting C-peptide and 2 hour postprandial C-peptide levels were lower in subjects with Ser/Ser genotype than in subjects with Gly/Gly genotype(P<0.05).There was no significance for insulin resistance among different genotypes both in DM and NC groups(P<0.05).Conclusion] The PGC-1α Gly482Ser polymorphism might be related to the development of type 2 diabetes in Chinese women.Ser/Ser seems to be associated with lower endogenous insulin secretion.
Keywords:diabetes mellitus/type 2  PGC-1α  polymorphism/genetics
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