NM23- H1、CD44V6在无淋巴结转移非小细胞肺癌中的表达及临床意义

[目的]探讨NM23-H1、CD44v6在无淋巴结转移的非小细胞肺癌(N0 NSCLC)中的表达及其临床意义.[方法]应用免疫组织化学的方法检测60例手术后病理证实N0 NSCLC组织NM23 - H1、CD44v6的表达,分析其表达与患者术后5年预后的关系.[结果] NM23 - H1及CD44v6的表达在鳞癌与腺癌...

Relation of NM23-H1 and CD44v6 expression to patient's prognosis in the non-small cell lung cancer without lymph node metastasis

[Objective] To research the expressions of NM23-H1、CD44v6 in the non-small cell lung cancer without lymph node metastasis(N0NSCLC)and their clinical significances.[Methods] The immunohistochemistry was used to detect the expressions of NM23-H1 and CD44v6 in 60 N0NSCLC from operatal patients and the relationship between the expressions and 5-years prognosis of patients after operation was analysed.[Results] Both of NM23-H1 and CD44v6 expressions were no significant differences between squamous cell carcinoma and adenocarcinoma.However,the expression of NM23-H1 related positively to 5-year survival rate of the patient(r=0.887),but that of CD44v6 negatively(r=-0.784).[Conclusion] Detection of NM23-H1 and CD44v6 expressions might be useful to predict the prognosis of patients with N0 NSCLC.