糖尿病患者的交感皮肤反应检测

目的]探讨糖尿病患者周围交感神经受损的情况。方法]对61例2型糖尿病患者和50例健康对照组进行了上下肢的交感皮肤反应（sympathetic skin response,SSR）检测。结果]SSR的起始潜伏期,上肢：糖尿病组（1385.3±246.7）ms与对照组（1361.2±123.2）ms差异具有显著性意义,P〈0.001;下肢：糖尿病组（1858.9±527.5）ms与对照组（1742.8±225.2）ms差异有显著性意义,P〈0.05;上下肢SSR波幅与对照组相比差异无显著性意义（P〉0.05）。糖尿病组SSR总异常率为41%,上肢异常率为17%,下肢异常率为41%,下肢异常率明显高于上肢,P〈0.001。结论]SSR是检测糖尿病交感神经损害的一种客观的、敏感的方法。此方法简单且无创伤,可作为糖尿病的常规电生理检测。

Test of sympathetic skin response in patients with diabetes mellitus

Objective] To study the injuries of peripheral sympathetic nerves in patients with T2DM(Type 2 diabetes mellitus).Methods] SSR(Sympathetic skin response) was tested in extremities of 61 T2DM patients and 50 healthy controls.Results] The initial latencies of SSR in upper limbs and lower limbs were prolonged significantly in T2DM group as compared to the control group upper limbs:T2DM group(1385.3±246.7) ms,control group:(1361.2±123.2)ms,P<0.001;lower limbs:T2DM group(1858.9±527.5)ms,control group:(1742.8±225.2)ms,P<0.05].There were no significant differences in Amplitudes of SSR between the two groups(P>0.05).The abnormal rate of SSR was 41% in T2DM group,17% in upper limbs,41% in lower limbs.The abnormal rate in lower limbs was significantly higher than in upper limbs(P<0.001).Conclusion] SSR is an objective method to detect injuries of sympathetic nerves in patients with diabetes mellitus.The method is simple and harmless.SSR can be used as a routine electrophysiological test in diabetic patients.