扶肾泄浊法对维持性血液透析患者微炎症状态的影响

目的：观察扶肾泄浊法（肾纤康颗粒）对维持性血液透析患者营养状态、微炎症状态的影响。方法：将40例维持性血液透析患者随机分为治疗组和对照组。治疗组在一般治疗基础上予肾纤康颗粒，对照组仅予一般治疗。治疗3月后观察2组体重、AMC、Alb、PA、TC、TG、HDL-C、LDL-C、Hb、CRP、TNF-α、IL-6水平变化。结果：治疗组干体重、MAMC、Alb、PA、Hb较治疗前明显升高（P〈0．05），CRP、TNF-α、IL-6均低于治疗前（P〈0．05）；与对照组比较，治疗组干体重、MAMC、舢b、PA、Hb3月后明显上升，差异有统计学意义（P〈0．05），CRP、TNF-α、IL-6均低于对照组（P〈0．05）；两组血TC、TG、HDL—C、LDL—c水平治疗前后差异无统计学意义（P〉0．05）。对照组CRP、TNF-α、IL-6均高于治疗前，但差异无统计学意义（P〉0．05）。结论：扶肾泄浊法通过增强患者食欲，抑制CRP、IL-6、INF-α的产生从而改善维持性血液透析患者营养不良、微炎症状态，减少心血管事件发生。

The effects of Fushen Xiezhuo therapy on microinflammatory state in maintenance hemodialytic patients

Objective To observe the effects of Fushen Xiezhuo therapy （by means of Shenxiankang Granules） on nutritional and microinflammatory state in maintenance hemodialytic patients. Methods： 40 Patients with maintained hemodialysis were randomized into treatment group , treated with Shenxiankang Granules plus general treatment,and the control group only received general treatment. 3 months later, the weight, AMC, Alb, PA, TC, TG, HDL-C, LDL-C, Hb, CRP, TNF- ot and IL-6 were checked. Results： In treatment group , dry body weight, MAMC,Alb,PA and Hb were significantly increased after treatment CRP,TNF- a and IL-6 were decreased （P 〈 0.05）. Dry body weight, MAMC, （P 〈 0.05）, while the levels of Alb, PA and Hb of treatment group were signifcantly higher （P 〈 0.05） ,while the levels of CRP, TNF- cL and IL-6 were lower than those of control group （P 〈 0.05）. After treatment, the levels of TC,TG, HDL-C and LDL-C had no significant change in both groups （P 〉 0.05）. In control group, levels of CRP,TNF- a and IL-6 were higher after treatment, but without statistical significance. Conclusion： Fushen Xiezhuo therapy can improve the maintenance hemodialytic patients＇ nutritional and microinflammatory state, and can reduce the incidence of cardiovascular events through stimulating appetite and inhibiting the production of CRP, IL-6 and TNF-α.