柴芍胃炎颗粒对功能性消化不良模型大鼠血浆胃动素与胃泌素的影响

目的：通过观察柴芍胃炎颗粒对功能性消化不良（functionaldyspepsia，FD）模型大鼠血浆胃动素、胃泌素的影响，探讨该药治疗功能性消化不良的可能机制。方法：将FD模型大鼠按随机化原则分为模型组，多潘立酮组，柴芍胃炎颗粒高、中、低组，同时与空白组比较，观察各组大鼠饮水、饮食、体重变化和胃排空率，用ELISA法测定血浆胃泌素（gastrin，GAS）、胃动素（motilin，MTL）。结果：胃泌素：各中药组、多潘立酮组较空白组明显升高（P〈0．05），但组间无明显差异（P〉0．05）；胃动素：中药高剂量组、中剂量组与正常空白组间无明显差异（P〉0．05），但较中药低剂量组及多潘立酮组升高（P〈O．05）。胃排空率：中药高剂量组、中剂量组与正常空白组间无明显差异（P〉0．05），高于低剂量组（P〈O．05）但较多潘立酮组低（P〈O．05）。结论：柴芍胃炎颗粒可能通过促进胃泌素、胃动素分泌和增加胃排空率，从而起到改善FD模型大鼠胃肠动力障碍的作用，但值得注意的是胃动素、胃排空率超过正常范围并不利于胃肠道消化吸收。

Eeffect of Chaishaoweiyan granules on the secretion of gastrin and motilin in rats with functional dyspepsia

Objective：To study the effect of Chaishaoweiyan （CSWY） granules on plasma motilin and gastrin in rats with functional dyspepsia （FD）, and to investigate its possible mechanism. Methods： The rats were randomly divided into six groups： model control group,domperidone group, high-medium-and low-CSWY granules groups, and normal control group; the change of intake of water and food, body weight, and gastric emptying rate were observed. The levels of plasma motilin and gastrin were measured by ELISA method. Results： The gastrin in CSWY groups and domperidone group was significantly higher than in normal control group （P 〈 0.05）, while there were no significant differences among the former four drug groups （P 〉 0.05）.No significant difference was noted in motilin among the normal control group, medium-and high-dose CSWY granules groups （P 〉 0.05）. However, the motilin in the former three groups were higher than that in doinperidone group and low-dose CSVd-Y granules group （P 〈 O.05）.The gastric emptying rates in normal control group, medium- and high-dose CSWY granules groups were higher than in low-dose CSWY granules group （P 〈 0.05）,but lower than in domperidone group （P 〈 0.05）. Conclusion： CSWY Granules may relieve gastric dynamic dysfunction in rats with functional dyspepsia （FD） by increasing the levels of plasma gastrin and motilin, and improving gastric emptying rate. It is worth to notice that the paranormal motilin and gastric emptying rate are not good for digestion and absorption.