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| 川芎嗪对肾小球疾病患者血浆内皮素和降钙素基因相关肽的影响 | |
| 引用本文： | 曹灵,孙兴旺,曹维,王泽卫,温向琼.川芎嗪对肾小球疾病患者血浆内皮素和降钙素基因相关肽的影响[J].泸州医学院学报,2001,24(4):274-276. |
| 作者姓名： | 曹灵 孙兴旺 曹维 王泽卫 温向琼 |
| 作者单位： | 1. 泸州医学院:附属医院肾病内科 2. 病理教研室,泸州,646000 3. 成都铁道通信设备厂成通医院 |
| 摘 要： | 目的：通过研究川芎嗪（tetramethyl pyrazine,TMP）对肾泪示疾病血浆内皮素（endothelin-1,ET-1）和降钙素基因相关肽（calcitonin gene related peptide,CGRP)的影响，探讨川芎嗪改善肾脏血液循环，保护肾功能的机理。方法：对肾小球疾病病例在同等治疗基础上，治疗组加用川芎嗪，对照组不用川芎嗪，分别检测两组病人治疗前和治疗后血浆中ET－1和CGRP含量。结果：治疗组治疗后与治疗前比较血浆中的ET－1下降和CGRP上升，均有特别显著性差异；对照组治疗前后比较，血浆中ET－1下降和CGRP上升，显著性差异。结论：川芎嗪治疗肾小球疾病可能是通过减少内皮细胞ET－1的产生和促进CGRP的生成，改善肾脏血液循环，对肾功能起保护作用。 |
| 关 键 词： | 肾小球疾病 川芎嗪 内皮素 降钙素基因相关肽 血管扩张药 |
| 文章编号： | 1000-2669(2001)04-0274-03 |
EFFECTS OF TETRAMETHYL PYRAZINE ON PLASMA ENDOTHELIN-1 AND CALCITONIN GENE RENE RELATED PEPTIDE OF PATIENTS WITH GLOMERULAR DISEASE |
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| Cao Ling,et al Pepartment of Nephrology,Luzhou Medical College Hospital.EFFECTS OF TETRAMETHYL PYRAZINE ON PLASMA ENDOTHELIN-1 AND CALCITONIN GENE RENE RELATED PEPTIDE OF PATIENTS WITH GLOMERULAR DISEASE[J].Journal of Luzhou Medical College,2001,24(4):274-276. | |
| Authors: | Cao Ling Pepartment of Nephrology Luzhou Medical College Hospital |
| Abstract: | Objective: To investigate the effects of TMP on plasma ET-1 and CGRP of glomerulur disease. Method: The patients with glomerular disease were randomly assigned to TMP treatment group and control group(without using TMP).Plasma ET-1and CGRP were measured before and after the treatment. Result: In the study TMP not only reduced plasma ET-1 ,but also increased plasma CGRP significantly. Conclusion: TMP has a renoprotective effect on renal function by reducing ET-1 and increasing CGRP. |
| Keywords: | Glomerular disease Tetramethyl pyrazine Endothelin Calcitonin gene related peptide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |