| 三氟拉嗪对异丙基肾上腺素性大鼠心肌线粒体损伤的影响 |
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| 引用本文： | 汪雄,董传仁,涂淑珍.三氟拉嗪对异丙基肾上腺素性大鼠心肌线粒体损伤的影响[J].郧阳医学院学报,1997(2). |
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| 作者姓名： | 汪雄 董传仁 涂淑珍 |
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| 作者单位： | 郧阳医学院病生教研室，湖北医科大学 |
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| 摘 要： | 目的：研究三氟拉嗪（ＴＦＰ）对缺血心肌线粒体损伤的影响。方法：采用异丙基肾上腺素性心肌梗塞（ＩＳＰ－ＭＩ，皮下注射ＩＳＰ４０ｍｇ／ｋｇ）为模型，观察了ＴＦＰ对缺血心肌线粒体丙二醛（ＭＤＡ）、膜脂流动性、超氧化物歧化酶（ＳＯＤ）及血清磷酸肌酸激酶（ＣＰＫ）的影响。结果：ＴＦＰ明显减轻ＩＳＰ－ＭＩ后心肌线粒体膜脂流动性及ＳＯＤ活力的降低（Ｐ＜０．０５），并显著减少了血清ＣＰＫ及心肌线粒体ＭＤＡ的升高（Ｐ＜０．０５）。结论：ＴＦＰ能部分对抗ＩＳＰ所致的心肌线粒体损伤，其机制可能与抗脂质过氧化作用有关。
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| 关 键 词： | 三氟拉嗪 异丙基肾上腺素 自由基过氧化脂质类 心肌缺血 |
Effect of Trifluoperazine on Myocardial Mitochondrial Injury Induced by Isoproterenol in Rats |
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| Abstract: | Objective:To investigate the effects of TFP on ischemic myocardial mitochondrial injury.Methods:On the model of myocardial ischemia induced by subcutaneous injection of isoproterenal(40 mg/kg) in rat,the effect of TFP on MDA,SOD and membrane lipid fluidity of myocardial mitochondrion and serum CPK was observed.Results:TFP apparently attenuated decrease of membrane lipid fluidity and SOD activity of ischemic myocardial mitochondrion(P<0.05),reduced markedly increase of MDA content in ischemic myocardial mitochondrion and serum CPK activity(P<0.05).Conclusion:TFP has a partial protective on ischemic myocardial mitochondrion, which probably resulted from its anti-peroxidation |
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| Keywords: | trifluoperazine isoproterenol lipidperoxides freeradicals myocardialischemia |
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