联合维生素治疗对血管性痴呆患者同型半胱氨酸水平的影响

目的:分析联合维生素治疗与血管性痴呆(vascular dementia,VD)患者高同型半胱氨酸(Homocysteine,Hcy)血症的相关性。方法:选取105例VD高Hcy血症患者,采用简易精神量表(MMSE)和日常生活能力量表(ADL)进行痴呆评分,联合维生素(叶酸、维生素B6、维生素B12)治疗,比较对照组和观察组治疗前后血浆Hcy水平、MMSE及ADL评分。结果:对照组治疗前后血浆Hcy水平、MMSE及ADL评分无显著性差异(P>0.05),观察组则有显著性差异(P<0.01)。结论:联合维生素治疗可明显降低血浆Hcy水平,减轻痴呆程度。

Effect of Combined Vitamin Therapy on Hyperhomocysteine in Vascular Dementia Patients

Objective To investigate the effect of combined vitamin therapy on hyperhomocysteine(Hcy) level in the vascular dementia patients.Methods One hundred and five vascular dementia patients with hyperhomocysteine were enrolled,and evaluated with MMSE and ADL.Folacin combined with vitamin B6 and vitamin B12 was given in the vascular dementia patients with hyperhomocysteine,and plasma Hcy level,MMSE and ADL was compared.Results After treatment,there was no significant difference in Hcy,MMSE,ADL in control group(P>0.05),and there was significantly statistic difference in vascular dementia patients(P<0.01).Conclusion Folacin with combination of vitamin B6 and vitamin B12 could decrease plasma Hcy level and may ameliorate the degree of vascular dementia.