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~(99)Tc~m-HL91探测存活心肌的应用研究
引用本文:刘刚,吴华,吴立兵,李伏燕,裴之俊,陈宇.~(99)Tc~m-HL91探测存活心肌的应用研究[J].郧阳医学院学报,2009,28(2).
作者姓名:刘刚  吴华  吴立兵  李伏燕  裴之俊  陈宇
作者单位:刘刚,吴立兵,李伏燕,裴之俊,陈宇,LIU Gang,WU Li-bing,LI Fu-yan,PEI Zhi-jun,CHEN Yu(郧阳医学院附属太和医院核医学科,湖北,十堰,442000);吴华,WU Hua(福建医科大学附属厦门第一医院核医学科,福建,厦门,361006)  
摘    要:目的:研究~(99)Tc~m-HL91在缺血心肌中的显像表现,探讨~(99)Tc~m-HL91探测缺氧但存活心肌的价值。方法:18例已确诊为心肌缺血或心肌梗塞的患者均行99Tcm-MIBI与~(99)Tc~m-HL91心肌灌注SPECT显像。在心脏短轴图像上通过ROI技术,获取缺血靶区(targetarea,T)与正常非靶区(non-targetarea,NT)心肌组织的平均放射性计数,计算T/NT比值,获得99Tcm-MIBI与99Tcm-HL91在局部缺血区与正常心肌组织的放射性比值。结果:99Tcm-HL91SPECT有10例患者在99Tcm-MIBI显像的放射性稀疏或缺损区可见到明显的放射性充填,其余8例患者~(99)Tc~m-HL91显像心肌摄取不高。结论:~(99)Tc~m-HL91可选择性地被存活/乏氧心肌摄取,和99Tcm-MIBISPECT联合应用,可有效提高检测存活心肌的效能。

关 键 词:心肌灌注显像  ~(99)Tc~m-HL91  存活心肌

Clinical Application of 99Tcm-HL91 SPECT on Viable Myocardium Detection
LIU Gang,WU Hua,WU Li-bing,LI Fu-yan,PEI Zhi-jun,CHEN Yu.Clinical Application of 99Tcm-HL91 SPECT on Viable Myocardium Detection[J].Journal of Yunyang Medical College,2009,28(2).
Authors:LIU Gang  WU Hua  WU Li-bing  LI Fu-yan  PEI Zhi-jun  CHEN Yu
Abstract:Objective To investigate the imaging characteristic of 99Tcm-HL91 in the ischemic myocardium and its value on the detection of hypoxic but viable myocardium.Methods 99Tcm-MIBI and 99Tcm-HL91 SPECT were performed in 18 patients with myocardial ischemia or infarction.The mean radioactive counts of myocardium in target area and non-target area were obtained from heart short axis images with ROI technique,the radioactivity ratio of target(ischemic area) to non-target(normal area) were calculated.Results In 10 patients the positive 99Tcm-HL91 uptake was shown in the defect region of 99Tcm-MIBI images.However,the remaining 8 patients showed low uptake of 99Tcm-HL91.Conclusion 99Tcm-HL91 may be selectively uptaken by hypoxic but viable myocardium,and the combination of 99Tcm-MIBI and 99Tcm-HL91 SPECT may be more helpful for accurate evaluation of viable myocardium.
Keywords:99Tcm-HL91
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