| 链脲菌素在糖尿病鼠模型中的应用及其作用机理 |
| |
| 引用本文： | 王芳,朱大菊,孙明谨,李雪锋.链脲菌素在糖尿病鼠模型中的应用及其作用机理[J].郧阳医学院学报,2004,23(1):15-17. |
| |
| 作者姓名： | 王芳 朱大菊 孙明谨 李雪锋 |
| |
| 作者单位： | 郧阳医学院附属太和医院内分泌科 湖北十堰442000
(王芳，朱大菊，孙明谨)，郧阳医学院附属太和医院内分泌科 湖北十堰442000(李雪锋) |
| |
| 摘 要： | 目的 :研究链脲菌素 (streptozotocin ,STZ)的作用机理 ,探讨其在糖尿病鼠模型中的应用方式和剂量。 方法 :选择大鼠、小鼠各 2 0只 ,随机各挑 10只分别作为对照组、实验组。实验组腹腔注射STZ ,对照组腹腔注射柠檬酸缓冲剂。观察血糖 (BS)、C肽结果。结果 :实验组BS均升高 ,C肽下降 ,和对照组相比 ,有显著性差异。结论 :STZ可破坏老鼠胰岛 β细胞功能 ,引起BS升高 ,小鼠对 180～ 2 0 0mg/kg耐受性较好 ,大鼠对 180～ 2 0 0mg/kg耐受性较差 ,对 6 5～ 70mg/kg耐受性较好。
|
| 关 键 词： | 链脲菌素 大鼠 小鼠 糖尿病 C肽 |
| 文章编号： | 1006-9674(2004)01-0015-03 |
| 修稿时间： | 2003年11月8日 |
The Role and its Mechanism of Streptozotocin in Diabetic Rat and Mouse |
| |
| WANG Fang,ZHU Da-ju,SUN Ming-jin et al..The Role and its Mechanism of Streptozotocin in Diabetic Rat and Mouse[J].Journal of Yunyang Medical College,2004,23(1):15-17. |
| |
| Authors: | WANG Fang ZHU Da-ju SUN Ming-jin |
| |
| Abstract: | Objective To study the mechanism of STZ,explore its use in the rat and mouse. Methods Twenty rats and twenty mice wer divided to experiment group and control group. The experiment group was injected STZ(ip),the control group was injected citric acid. Buffer glucose and C-peptide were obsered.Results The glucose of the experiment group was rised. The C-peptide was declined,there was a significant difference between the experimentgroup and control group.Conclusions STZ can destroy the rat and mouse islet B cell funtion,induce diabetes. The mouse can endure STZ 180～200 mg/kg, the rat can endure STZ 65～70 mg/kg. |
| |
| Keywords: | Streptozotocin Rats Mice Diabetes Mellitus C-Peptide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
