微血管密度与胃癌侵袭和转移的关系

目的 :探讨胃癌组织中微血管密度 (MVD)与胃癌生物学行为的关系。方法 :应用免疫组织化学S -P法和抗人因子Ⅷ相关抗原 (FⅧ -RAg)的抗体 ,标记 6 8例胃癌组织中的微血管 ,检测MVD。分析其与胃癌组织学类型、分化水平、浸润深度及淋巴结转移的关系。结果 :6 8例胃癌组织中FⅧ -RAg阳性表达 5 2例 ,占 76 .4 7%。FⅧ -RAg和MVD与分化水平、浸润深度 (P <0 .0 1)及淋巴结转移 (P <0 .0 0 1)密切相关。不同组织学类型中FⅧ-RAg的表达具有显著相关性 (P <0 .0 1) ,而MVD则与胃癌组织学类型无显著差异 (P >0 .0 5 )。 结论 :血管生成对胃癌的发展具有一定作用 ,FⅧ -RAg的检测和MVD可作为判断胃癌恶性程度和预后的生物学指标。

Relationship between microvessel density and invasion, metastasis in gastric carcinoma

Objective To explore the relationship of microvessel density (MVD) and biological behavior of human gastric carcinoma.Methods MVD was determined by immunohistochemical S-P staining in gastric carcinoma tissues with anti-human factor Ⅷ-related antigen ( FⅧ-RAg) Antibody, and the relation between MVD and histological types, depth of invasion, lymph nodes metastasis was analyzed.Results 52 cases of 68 cases were positive for FⅧ-RAg (76.47%),the value of FⅧ-RAg and MVD was correlatiated with differentiated level,depth of invasion ( P <0.01) and lymph nodes metastasis ( P <0.001). The expression of FⅧ-RAg were related to the histologic types ( P <0.01), but MVD relation to the histologic types of gastric carcinoma was not significant ( P >0.05).Conclusion Angiogensis have an important role in the progression of gastric carcinoma. The expression of FⅧ-RAg and MVD may be a good prognostic indicator for patient with gastric carcinoma.