| IL-18基因启动子-607C/A位点多态性与冠心病关系的研究 |
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| 引用本文： | 朱名安,吕军,宋惠,刘兴晖,朱静.IL-18基因启动子-607C/A位点多态性与冠心病关系的研究[J].郧阳医学院学报,2011(5):471-474,479. |
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| 作者姓名： | 朱名安 吕军 宋惠 刘兴晖 朱静 |
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| 作者单位： | 湖北医药学院附属太和医院检验部;湖北医药学院基础医学院;湖北医药学院附属东风医院检验科; |
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| 基金项目： | 湖北省教育厅重点项目(2003A012) |
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| 摘 要： | 目的:探讨汉族人群IL-18基因启动子-607C/A位点多态性与冠心病(CHD)发生之间的关系。方法:应用序列特异性引物-聚合酶链反应技术,检测141例CHD患者和240例健康对照者IL-18基因启动子-607C/A单核苷酸多态性位点基因型,分析CHD组和对照组基因型频率和等位基因频率分布;同时进行血脂检测。结果:CHD组和健康对照组IL-18基因启动子-607C/A位点的基因型CC、CA、AA频率分别为33.3%、50.4%、16.3%和21.3%、51.3%、27.4%,等位基因C和A的频率分别为58.5%、41.5%和46.9%、53.1%。CHD组CC基因型和C等位基因频率明显高于健康对照组(χ2=4.56,P=0.03;χ2=7.49,P=0.01),具有显著性差异。结论:IL-18基因启动子-607C/A位点CC基因型人群冠心病易感性增高,C等位基因可能是CHD发生的一个遗传危险因子。
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| 关 键 词： | 白细胞介素18 冠心病 单核苷酸多态性 |
Study on the Correlation Between Interleukin(IL)-18 gene Promoter-607 A/C Polymorphism and Risk of CHD |
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| ZHU Ming-an,LV Jun,SONG Hui,LIU Xing-hui,ZHU Jing.Study on the Correlation Between Interleukin(IL)-18 gene Promoter-607 A/C Polymorphism and Risk of CHD[J].Journal of Yunyang Medical College,2011(5):471-474,479. |
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| Authors: | ZHU Ming-an LV Jun SONG Hui LIU Xing-hui ZHU Jing |
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| Institution: | ZHU Ming-an1,2,LV Jun1,SONG Hui3,LIU Xing-hui3,ZHU Jing1(1Department of Clinical Laboratory,Taihe Hospital,2Faculty of Basic Medicne,3Department of Clinical Laboratory,Dongfeng Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To investigate the correlation between interleukin(IL)-18 gene promoter-607 A/C polymorphism and the risk of CHD in Chinese Han population.Methods The single nucleotide polymorphism at the position of interleukin(IL)-18 gene promoter-607 A/C were detected by sequence specific primer-polymerase chain reaction(SSP-PCR) in 141 patients with CHD and 240 healthy controls.The genotype and allele frequencies were analyzed in both CHD group and control group.Meanwhile,the blood lipids were measured by enz... |
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| Keywords: | Interleukin 18 Coronary heart disease Single nucleotide polymorphism |
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